IS 741 manufacturers
- Fuzapladib
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- $58.00 / 1mg
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2026-04-12
- CAS:141283-87-6
- Min. Order:
- Purity: 99.87%
- Supply Ability: 10g
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| Product Name: | IS 741 | | Synonyms: | IS 741;IS-741
(Fuzapladib;Cyclohexanecarboxamide, N-[2-[(ethylsulfonyl)amino]-5-(trifluoromethyl)-3-pyridinyl]-;Fuzapladib （IS-741）;Fuzapladib;N-(2-(Ethylsulfonamido)-5-(trifluoromethyl)pyridin-3-yl)cyclohexanecarboxamide;Fuzapladib, 10 mM in DMSO | | CAS: | 141283-87-6 | | MF: | C15H20F3N3O3S | | MW: | 379.4 | | EINECS: | | | Product Categories: | | | Mol File: | 141283-87-6.mol |  |
| | IS 741 Chemical Properties |
| density | 1.411±0.06 g/cm3(Predicted) | | storage temp. | -10 to -25°C | | solubility | DMSO: 2mg/mL, clear | | pka | 5.41±0.10(Predicted) | | form | Solid | | color | White to off-white | | InChI | InChI=1S/C15H20F3N3O3S/c1-2-25(23,24)21-13-12(8-11(9-19-13)15(16,17)18)20-14(22)10-6-4-3-5-7-10/h8-10H,2-7H2,1H3,(H,19,21)(H,20,22) | | InChIKey | TUWCZRFHNIOVTC-UHFFFAOYSA-N | | SMILES | C1(C(NC2=CC(C(F)(F)F)=CN=C2NS(CC)(=O)=O)=O)CCCCC1 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | IS 741 Usage And Synthesis |
| Uses | Fuzapladib (IS-741), an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site[1][2]. | | Biological Activity | Fuzapladib (IS-741) is a cell penetrant and potent phospholipase A2 (PLA2) inhibitor. Fuzapladib decelerate the progression of pancreatic fibrosis through monocyte infiltration in dogs. | | in vivo | Fuzapladib (IS-741) (p.o., 50 mg/kg, 7 days) inhibits neutrophil infiltration into inflamed lesions, and is effective for attenuating rat trinitrobenzene sulfonic acid (TNBS) ileitis[4]. | Animal Model: | Rats[4] | | Dosage: | 50 mg/kg | | Administration: | P.o.; for 7 days | | Result: | Significantly reduced myeloperoxidase (MPO) activity and mucosal IL-8 levels in rat ileum, reduced polymorphonuclear cells and Mac-1 positivity Infiltration of cells into inflammatory lesions, effectively alleviated trinitrobenzenesulfonic acid (TNBS)-induced ileitis. |
| | References | [1] Noriyuki Kaji, et al. Fuzapladib reduces postsurgical inflammation in the intestinal muscularis externa. J Vet Med Sci. 2023 Sep 21. DOI:10.1292/jvms.23-0257
[2] C Bassi. IS-741 (Ishihara Sangyo). Curr Opin Investig Drugs. 2001 Apr;2(4):510-2. PMID:11566008
[3] Shikama H, et al. Effect of IS-741 on cell adhesion between human umbilical vein endothelial cells and HL-60 cells. Biol Pharm Bull. 1999 Feb;22(2):127-31. DOI:10.1248/bpb.22.127
[4] Tetsuya Fukunaga, et al. A novel diamino-pyridine derivative (IS-741) attenuates rat ileitis induced by trinitrobenzene sulfonic acid. J Gastroenterol. 2003;38(5):451-9. DOI:10.1007/s00535-002-1081-8 |
| | IS 741 Preparation Products And Raw materials |
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