(2E)-3-[3-[6-[(4-Piperidinylmethyl)amino]-2-pyrazinyl]phenyl]-2-propenoic acid

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(2E)-3-[3-[6-[(4-Piperidinylmethyl)amino]-2-pyrazinyl]phenyl]-2-propenoic acid Basic information
Product Name:(2E)-3-[3-[6-[(4-Piperidinylmethyl)amino]-2-pyrazinyl]phenyl]-2-propenoic acid
Synonyms:(2E)-3-[3-[6-[(4-Piperidinylmethyl)amino]-2-pyrazinyl]phenyl]-2-propenoic acid;PIM-IN-2
CAS:1006699-45-1
MF:C19H22N4O2
MW:338.4
EINECS:
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Mol File:1006699-45-1.mol
(2E)-3-[3-[6-[(4-Piperidinylmethyl)amino]-2-pyrazinyl]phenyl]-2-propenoic acid Structure
(2E)-3-[3-[6-[(4-Piperidinylmethyl)amino]-2-pyrazinyl]phenyl]-2-propenoic acid Chemical Properties
Boiling point 592.7±50.0 °C(Predicted)
density 1.231±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka4.24±0.10(Predicted)
Safety Information
MSDS Information
(2E)-3-[3-[6-[(4-Piperidinylmethyl)amino]-2-pyrazinyl]phenyl]-2-propenoic acid Usage And Synthesis
UsesPIM-IN-2 (Pim-2) is a Pim kinases inhibitor (IC50 = 25 nM). PIM-IN-2 promotes cell survival, is antiapoptotic, and has exhibited an elevated level of expression in a variety of human tumors[1].
IC 50PIM2
References[1] Qian K, et al. Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode [J]. Journal of medicinal chemistry, 2009, 52(7): 1814-1827. DOI:10.1021/jm801242y
(2E)-3-[3-[6-[(4-Piperidinylmethyl)amino]-2-pyrazinyl]phenyl]-2-propenoic acid Preparation Products And Raw materials
Tag:(2E)-3-[3-[6-[(4-Piperidinylmethyl)amino]-2-pyrazinyl]phenyl]-2-propenoic acid(1006699-45-1) Related Product Information
2-Propenoic acid, 3-[3-[6-(hexahydro-4-Methyl-1H-1,4-diazepin-1-yl)-2-pyrazinyl]phenyl]-, (2E)- (2E)-3-[3-[6-[(4-Piperidinylmethyl)amino]-2-pyrazinyl]phenyl]-2-propenoic acid AZD-1208 2-[[3-(4-Morpholinyl)propyl]amino]-4-pyridinecarboxylic acid 2-[1-(4-chloro-2-hydroxyphenyl)propylidene]hydrazide GDC-0339 JP-11646