| Company Name: |
Suzhou Zhixin Biotechnology Co., Ltd.
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| Tel: |
0512-65118909 18100677375 |
| Email: |
sales@szzxbio.com |
| Products Intro: |
Product Name:PIM-IN-2
CAS:1006699-45-1
Purity:98%+ Package:1g;10g;100g
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:PIM-IN-2
CAS:1006699-45-1
Package:5mg;50mg
|
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| | (2E)-3-[3-[6-[(4-Piperidinylmethyl)amino]-2-pyrazinyl]phenyl]-2-propenoic acid Basic information |
| | (2E)-3-[3-[6-[(4-Piperidinylmethyl)amino]-2-pyrazinyl]phenyl]-2-propenoic acid Chemical Properties |
| Boiling point | 592.7±50.0 °C(Predicted) | | density | 1.231±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | | pka | 4.24±0.10(Predicted) |
| | (2E)-3-[3-[6-[(4-Piperidinylmethyl)amino]-2-pyrazinyl]phenyl]-2-propenoic acid Usage And Synthesis |
| Uses | PIM-IN-2 (Pim-2) is a Pim kinases inhibitor (IC50 = 25 nM). PIM-IN-2 promotes cell survival, is antiapoptotic, and has exhibited an elevated level of expression in a variety of human tumors[1]. | | IC 50 | PIM2 | | References | [1] Qian K, et al. Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode [J]. Journal of medicinal chemistry, 2009, 52(7): 1814-1827. DOI:10.1021/jm801242y |
| | (2E)-3-[3-[6-[(4-Piperidinylmethyl)amino]-2-pyrazinyl]phenyl]-2-propenoic acid Preparation Products And Raw materials |
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