| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
marketing1@energy-chemical.com |
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| Product Name: | C 1311 | | Synonyms: | C 1311;5-((2-(Diethylamino)ethyl)amino)-8-hydroxy-6H-imidazo[4,5,1-de]acridin-6-one;XLS-002;Symadex;CUNDRHORZHFPLY-UHFFFAOYSA-N;Symadex >=98% (HPLC);6H-Imidazo[4,5,1-de]acridin-6-one, 5-[[2-(diethylamino)ethyl]amino]-8-hydroxy- | | CAS: | 138154-39-9 | | MF: | C20H22N4O2 | | MW: | 350.41 | | EINECS: | | | Product Categories: | | | Mol File: | 138154-39-9.mol |  |
| | C 1311 Chemical Properties |
| Boiling point | 605.8±65.0 °C(Predicted) | | density | 1.32±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble10mg/mL (clear solution; warmed) | | form | powder | | pka | 8.35±0.20(Predicted) | | color | white to beige | | InChI | 1S/C20H22N4O2/c1-3-23(4-2)10-9-21-15-6-7-16-19-18(15)20(26)14-11-13(25)5-8-17(14)24(19)12-22-16/h5-8,11-12,21,25H,3-4,9-10H2,1-2H3 | | InChIKey | CUNDRHORZHFPLY-UHFFFAOYSA-N | | SMILES | CCN(CC)CCNc1ccc2ncn3-c4ccc(O)cc4C(=O)c1c23 |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | C 1311 Usage And Synthesis |
| Uses | C-1311 shows to inhibit the catalytic activity of DNA topoisomerase II in vitro and in tumour cells. C-1311 prolongs G2 arrest followed by G2 to M transit and cell death during mitosis in the process of mitotic catastrophe[1]. | | Biological Activity | Symadex is an FMS-like tyrosine kinase 3 (FLT3) and topoisomerase-II inhibitor; ABCG2 substrate; cell cycle modulator. | | References | [1] Magdalena Hyzy, et al. Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells. Biochem Pharmacol. 2005 Mar 1;69(5):801-9. DOI:10.1016/j.bcp.2004.11.028 |
| | C 1311 Preparation Products And Raw materials |
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