SK&f 89976-a manufacturers
- SKF89976A HCl
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- $1520.00
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2026-05-11
- CAS:85375-85-5
- Purity:
- Supply Ability: 10g
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| | SK&f 89976-a Basic information |
| Product Name: | SK&f 89976-a | | Synonyms: | 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid;SKF-89976;3-Piperidinecarboxylic acid, 1-(4,4-diphenyl-3-buten-1-yl)- | | CAS: | 85375-85-5 | | MF: | C22H25NO2 | | MW: | 335.44 | | EINECS: | | | Product Categories: | | | Mol File: | 85375-85-5.mol |  |
| | SK&f 89976-a Chemical Properties |
| Boiling point | 531.4±50.0 °C(Predicted) | | density | 1.121±0.06 g/cm3(Predicted) | | pka | 3.87±0.20(Predicted) |
| | SK&f 89976-a Usage And Synthesis |
| Description | SKF89976A is a potent GABA uptake inhibitor, which is selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). SKF89976A inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). It is able to pass the blood-brain barrier after systemic administration and is active in vivo. | | Uses | SKF89976A is a selective GABA transporter (GAT-1) inhibitor with IC50s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively. | | Definition | ChEBI: 1-(4,4-diphenylbut-3-enyl)-3-piperidinecarboxylic acid is a diarylmethane. | | in vivo | SKF89976A produces a weak antiallodynic response when administered i.v. (0.3 mg/kg). The i.t. injection of SKF89976A dose-dependently ameliorates the reduction in the withdrawal threshold in PSL model mice[1]. | | References | [1] Jinzenji A, et al. Antiallodynic action of 1-(3-(9H-Carbazol-9-yl)-1-propyl)-4-(2-methyoxyphenyl)-4-piperidinol (NNC05-2090), a betaine/GABA transporter inhibitor. J Pharmacol Sci. 2014;125(2):217-26. DOI:10.1254/jphs.13146fp
[2] Kreitzer MA, et al. Glutamate modulation of GABA transport in retinal horizontal cells of the skate. J Physiol. 2003 Feb 1;546(Pt 3):717-31. DOI:10.1113/jphysiol.2002.034421
[3] Barakat L, et al. GAT-1 and reversible GABA transport in Bergmann glia in slices. J Neurophysiol. 2002 Sep;88(3):1407-19. DOI:10.1152/jn.2002.88.3.1407 |
| | SK&f 89976-a Preparation Products And Raw materials |
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