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| | N-methyl-N-nitrosoacetamide Basic information |
| | N-methyl-N-nitrosoacetamide Chemical Properties |
| Boiling point | 191.38°C (rough estimate) | | density | 1.3516 (rough estimate) | | refractive index | 1.4715 (estimate) | | Water Solubility | 17.36g/L(24 ºC) | | Henry's Law Constant | 8.6×10-2 mol/(m3Pa) at 25℃, Mirvish et al. (1976) |
| | N-methyl-N-nitrosoacetamide Usage And Synthesis |
| Uses | N-methyl-N-nitrosoacetamide is an alkylating agent; a source of diazomethane; can be used as an activated acylating agent and as a precursor to esters and olefins. | | Preparation | Nitrosation of N-alkyl amides with Sodium Nitrite/acid mixtures, Nitrosyl Chloride, or Nitrogen Dioxide. N-Deprotonation of the amide with n-Butyllithium or Sodium Hydride, followed by treatment with nitrosonium salts or Nitrogen Dioxide, is a second approach that is particularly useful in the preparation of thermally labile nitrosoamides. | | Safety Profile | Poison by ingestion.
Questionable carcinogen with experimental
tumorigenic data. Mutation data reported.
When heated to decomposition it emits
toxic fumes of NOx. |
| | N-methyl-N-nitrosoacetamide Preparation Products And Raw materials |
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