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Araprofen

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Araprofen Basic information
Product Name:Araprofen
Synonyms:Araprofen;Benzeneacetic acid, 4-[(2-carboxyphenyl)amino]-α-methyl-
CAS:15250-13-2
MF:C16H15NO4
MW:285.29
EINECS:
Product Categories:
Mol File:15250-13-2.mol
Araprofen Structure
Araprofen Chemical Properties
Melting point 191-192 °C(Solv: acetonitrile (75-05-8))
Boiling point 496.6±35.0 °C(Predicted)
density 1.341±0.06 g/cm3(Predicted)
pka3.69±0.36(Predicted)
Safety Information
MSDS Information
Araprofen Usage And Synthesis
OriginatorAraprofen,Onbio Inc.
Manufacturing ProcessA mixture of 2-(4-aminophenyl)propionic acid (52.2 g), potassium ochlorobenzoate (61.5 g), potassium carbonate (43.6 g) and copper powder (0.3 g) in amyl alcohol (620 ml) is heating under reflux for 16 h. The major proportion of the solvent is then removed by steam distillation. The residual aqueous solution is treated with decolorising charcoal (20.0 g) and acidified with 4 N sulfuric acid (220 ml). The cream product which crystallises is dissolved in diethyl ether (500 ml).
The aqueous mother liquors are extracted with methylene chloride (900 ml). The organic phases are combined, washed with water (800 ml) and dried over anhydrous sodium sulfate. After filtration, the filtrate is concentrated to dryness under a pressure of 20 mm Hg to give a semicrystalline paste (65.0 g) which is recrystallised from acetonitrile (550 ml). The crystals are filtered off, and the product recovered (32.0 g) is recrystallised from acetonitrile (600 ml). There is thus obtained 2-[4-(2-carboxyphenyl)aminophenyl]propionic acid (18.4 g) melting point 191°-192°C.
Therapeutic FunctionAntiinflammatory, Analgesic
Araprofen Preparation Products And Raw materials
Raw materials2-(4-AMINO-PHENYL)-PROPIONIC ACID-->Sulfuric acid-->Potassium carbonate
Tag:Araprofen(15250-13-2) Related Product Information
2-[(4-METHYLPHENYL)AMINO]BENZOIC ACID N-Phenylanthranilic acid Araprofen
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