α-Conotoxin ImI (trifluoroacetate salt) manufacturers
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| | α-Conotoxin ImI (trifluoroacetate salt) Basic information |
| | α-Conotoxin ImI (trifluoroacetate salt) Chemical Properties |
| solubility | Water: soluble |
| | α-Conotoxin ImI (trifluoroacetate salt) Usage And Synthesis |
| Description | α-Conotoxin ImI is a conotoxin that has been found in C. imperialis and has receptor antagonist and anticancer activities.1 It is a peptide antagonist of homomeric α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 220 nM). α-Conotoxin ImI is selective for α7 nAChRs over α2β2, α3β2, α4β2, α2β4, α3β4, α4β4, and α1β1γδ subunit-containing nAChRs at 5 µM but does inhibit homomeric α9 nAChRs (IC50 = 1,800 nM). Administration of paclitaxel (Item No. 10461) in micelles containing α-conotoxin ImI decreases tumor growth in an MCF-7 mouse xenograft model.2 Intracerebroventricular, but not intraperitoneal, administration of α-conotoxin ImI (20 nmol/animal) induces seizures in rats.3WARNING This product is not for human or veterinary use. | | References | [1] D S JOHNSON. alpha-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric alpha 7 and alpha 9 receptors.[J]. Molecular Pharmacology, 1995, 48 2: 194-199.
[2] DONG MEI. The use of α-conotoxin ImI to actualize the targeted delivery of paclitaxel micelles to α7 nAChR-overexpressing breast cancer.[J]. Biomaterials, 2015, 42: 52-65. DOI: 10.1016/j.biomaterials.2014.11.044
[3] J M MCINTOSH. A nicotinic acetylcholine receptor ligand of unique specificity, alpha-conotoxin ImI.[J]. The Journal of Biological Chemistry, 1994, 269 24: 16733-16739.
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| | α-Conotoxin ImI (trifluoroacetate salt) Preparation Products And Raw materials |
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