-Conotoxin MVIIC (trifluoroacetate salt)

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-Conotoxin MVIIC (trifluoroacetate salt) Suppliers list
Company Name: Cayman Chemical Company  
Tel: (800) 364-9897
Email: cayman@caymanchem.com
-Conotoxin MVIIC (trifluoroacetate salt) Basic information
Product Name:-Conotoxin MVIIC (trifluoroacetate salt)
Synonyms:-Conotoxin MVIIC (trifluoroacetate salt)
CAS:
MF:C106H178N40O32S7
MW:2749.25132
EINECS:
Product Categories:
Mol File:Mol File
-Conotoxin MVIIC (trifluoroacetate salt) Structure
-Conotoxin MVIIC (trifluoroacetate salt) Chemical Properties
solubility Water: 1 mg/ml
Safety Information
MSDS Information
-Conotoxin MVIIC (trifluoroacetate salt) Usage And Synthesis
Descriptionω-Conotoxin MVIIC is a peptide originally isolated from the marine mollusk C. magus.1 It blocks N-type calcium channels on rat superior cervical ganglions (SCGs) and P-type calcium channels on rat Purkinje neurons (Kds = 30 and ~50 nM, respectively, in the presence of 5 mM barium).2 It also blocks Q-type channels in rat CA3 neurons. ω-Conotoxin MVIIC binds to rat brain membranes (IC50 = 0.3 nM) and completely blocks calcium uptake by rat brain synaptosomes when used at a concentration of 2.5 μM in the presence of 5 mM potassium.1 It blocks potassium-evoked dopamine (Item No. 21992) release from rat striatal slices (IC50 = ~128 nM) and potassium-evoked calcium-dependent glutamate release from rat brain synaptosomes.3,4WARNING This product is not for human or veterinary use.
References[1] D R HILLYARD. A new Conus peptide ligand for mammalian presynaptic Ca2+ channels.[J]. Neuron, 1992, 9 1: 69-77. DOI: 10.1016/0896-6273(92)90221-x
[2] SINEAD MCDONOUGH. Inhibition of calcium channels in rat central and peripheral neurons by omega-conotoxin MVIIC[J]. Journal of Neuroscience, 1996, 152 1: 2612-2623. DOI: 10.1523/jneurosci.16-08-02612.1996
[3] DOBROMIR DOBREV  Klaus A. Modulation of Potassium-Evoked [3H]Dopamine Release from Rat Striatal Slices by Voltage-Activated Calcium Channel Ligands: Effects of ω-Conotoxin-MVIIC[J]. Neurochemical Research, 1997, 22 9: 1085-1093. DOI: 10.1023/a:1027305016440
[4] T J TURNER  K D  R A Lampe. Characterization of presynaptic calcium channels with omega-conotoxin MVIIC and omega-grammotoxin SIA: role for a resistant calcium channel type in neurosecretion.[J]. Molecular Pharmacology, 1995, 47 2: 348-353.
-Conotoxin MVIIC (trifluoroacetate salt) Preparation Products And Raw materials
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