| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:CDK/HDAC-IN-3
CAS:2944087-54-9
Package:1removed
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CDK/HDAC-IN-3 manufacturers
- CDK/HDAC-IN-3
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- $1970.00
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2026-05-11
- CAS:2944087-54-9
- Purity:
- Supply Ability: 10g
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| | CDK/HDAC-IN-3 Basic information |
| Product Name: | CDK/HDAC-IN-3 | | Synonyms: | CDK/HDAC-IN-3;1H-Pyrazole-3-carboxamide, N-[4-[[(2-aminophenyl)amino]carbonyl]phenyl]-4-[(2,6-dichlorobenzoyl)amino]- | | CAS: | 2944087-54-9 | | MF: | C24H18Cl2N6O3 | | MW: | 509.34 | | EINECS: | | | Product Categories: | | | Mol File: | 2944087-54-9.mol |  |
| | CDK/HDAC-IN-3 Chemical Properties |
| Boiling point | 594.904±50.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.573±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | form | Solid | | pka | 11.040±0.70(predicted) | | color | White to yellow |
| | CDK/HDAC-IN-3 Usage And Synthesis |
| Uses | CDK/HDAC-IN-3 is an orally active HDACs/CDKs dual inhibitor. CDK/HDAC-IN-3 has potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2 and HDAC3 with IC50 values of 98.32 nM, 98.85 nM, 100 nM, 62.12 nM, 93.28nM and 82.87 nM. CDK/HDAC-IN-3 can be used for the acute myeloid leukemia (AML) [1]. | | in vivo | CDK/HDAC-IN-3 (compound 33a) (i.v., p.o.; 5, 25 mg/kg) has relatively adequate oral bioavailability[1].
| Animal Model: | Sprague-Dawley male rats (220-350 g)[1] | | Dosage: | 5 mg/kg and 25 mg/kg | | Administration: | IV and PO | | Result: | | PK parameters | i.v (5 mg/Kg) | p.o (25 mg/Kg) | | Cmax(ng/L) | 3644.00 | 1426.00 | | T1/2(h) | 0.11 | 1.37 | | TMax(h) | NA | 0.75 | | Clearance (mL/h/kg) | 5307.00 | 1726.00 | | MRT (h) | 0.39 | 1.27 | | AUC (ng.h/mL) | 836.00 | 2368.00 | | F% | NA | 56.70% |
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| | References | [1] Liu Y, et al. Discovery of novel and bioavailable histone deacetylases and cyclin-dependent kinases dual inhibitor to impair the stemness of leukemia cells. Eur J Med Chem. 2023;249:115140. DOI:10.1016/j.ejmech.2023.115140 |
| | CDK/HDAC-IN-3 Preparation Products And Raw materials |
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