Product Details
| Product Name:
CDK/HDAC-IN-3 |
CAS No.:
2944087-54-9 |
| Supply Ability:
10g |
Release date:
2025/04/27 |
Product Introduction
Bioactivity
| Name | CDK/HDAC-IN-3 |
| Description | CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3, with IC50 values of 98.32 nM, 98.85 nM, 100 nM, 62.12 nM, 93.28 nM, and 82.87 nM, respectively, and is applicable in the treatment of acute myeloid leukemia (AML) [1]. |
| In vitro | CDK/HDAC-IN-3 (compound 33a) at 1 μM demonstrates potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3 with IC50 values of 98.32 nM, 98.85 nM, 100 nM, 62.12 nM, 93.28 nM, and 82.87 nM, respectively [1]. At 0.5 μM and 1.0 μM, this compound significantly induces the differentiation of leukemia stem cell-like cells and inhibits AML proliferation [1]. Additionally, at 0.5 μM, 1.0 μM, and 2.0 μM, CDK/HDAC-IN-3 markedly promotes the differentiation of LSCs [1]. The compound also exhibits inhibitory effects on U937, HL-60, SKNO-1, and Kasumi-1 cells with IC50 values of 0.72 μM, 1.43 μM, 1.63 μM, and 0.89 μM, respectively [1]. |
| In vivo | CDK/HDAC-IN-3 (compound 33a) demonstrates good oral bioavailability when administered intravenously (i.v.) at 5 mg/kg and orally (p.o.) at 25 mg/kg [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Inhibitors Related | Panobinostat | Theophylline monohydrate | Valproic acid sodium salt | Sodium 4-phenylbutyrate | Acefylline | Vorinostat | Valproic Acid | Curcumin | Parthenolide | 4-Phenylbutyric acid | Theophylline | Methyl L-histidinate dihydrochloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
-
CAS:2421122-61-2
$1980.00 / 50mg
-
CAS:2580938-58-3
$2500.00 / 100mg
-
CAS:2700035-54-5
$1980.00 / 50mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$34.00/1mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2025-04-29 |
|
|
$40.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2025-05-19 |
|
|
$0.00/1g |
VIP1Y
|
Wuhan Circle Star Chem-medical Technology Co.,Ltd
|
2025-01-17 |
United States