NMS-0963

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NMS-0963 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
NMS-0963 Basic information
Product Name:NMS-0963
Synonyms:NMS-0963;1H-Pyrazole-5-carboxamide, N-[(1S)-2-(1-azetidinyl)-1-methylethyl]-3-[2-[(3,5-dimethoxyphenyl)amino]-4-pyrimidinyl]-1-methyl-
CAS:2765304-82-1
MF:C23H29N7O3
MW:451.52
EINECS:
Product Categories:
Mol File:2765304-82-1.mol
NMS-0963 Structure
NMS-0963 Chemical Properties
density 1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka13.99±0.46(predicted)
Safety Information
MSDS Information
NMS-0963 Usage And Synthesis
UsesNMS-0963 (compound 1) is an inhibitor of spleen tyrosine kinase (SYK) with an oral activity and IC50 value of 3 nM. NMS-0963 inhibits BaF3-TEL/SYK cell line proliferative at 27 nM[1].
References[1] Giovanni Cervi, et al. Discovery and optimization of 4-pyrazolyl-2-aminopyrimidine derivatives as potent spleen tyrosine kinase (SYK) inhibitors. Eur J Med Chem. 2024. DOI:10.1016/j.ejmech.2024.116375
NMS-0963 Preparation Products And Raw materials
Tag:NMS-0963(2765304-82-1) Related Product Information
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