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| | TDI-8304 Basic information |
| Product Name: | TDI-8304 | | Synonyms: | TDI-8304;2-Oxa-8,11-diazabicyclo[13.3.1]nonadeca-1(19),15,17-triene-7-carboxamide, N-cyclopentyl-10-[2-(4-morpholinyl)ethyl]-9,12-dioxo-13-(2-oxo-1-pyrrolidinyl)-, (7S,10S,13S)- | | CAS: | 2307262-96-8 | | MF: | C32H47N5O6 | | MW: | 597.75 | | EINECS: | | | Product Categories: | | | Mol File: | 2307262-96-8.mol |  |
| | TDI-8304 Chemical Properties |
| Boiling point | 922.619±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.261±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 13.481±0.70(predicted) |
| | TDI-8304 Usage And Synthesis |
| Uses | TDI-8304, a macrocyclic peptide, is a potent, species selective, and noncovalent Plasmodium falciparum (Pf20S) inhibitor. TDI-8304 shows highly selective for Pf20S over human proteasomes[1]. | | References | [1] Hao-Chi Hsu, et al. Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors. Nat Commun. 2023 Dec 14;14(1):8302. DOI:10.1038/s41467-023-44077-2 |
| | TDI-8304 Preparation Products And Raw materials |
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