Pyrido[3,2-c]pyridazin-3(2H)-one, 4-[4-(difluoromethoxy)phenyl]-6-ethoxy-2-(2-methyl-2H-indazol-5-yl)-

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Pyrido[3,2-c]pyridazin-3(2H)-one, 4-[4-(difluoromethoxy)phenyl]-6-ethoxy-2-(2-methyl-2H-indazol-5-yl)- Basic information
Product Name:Pyrido[3,2-c]pyridazin-3(2H)-one, 4-[4-(difluoromethoxy)phenyl]-6-ethoxy-2-(2-methyl-2H-indazol-5-yl)-
Synonyms:Pyrido[3,2-c]pyridazin-3(2H)-one, 4-[4-(difluoromethoxy)phenyl]-6-ethoxy-2-(2-methyl-2H-indazol-5-yl)-;MAT2A inhibitor 6
CAS:2447686-21-5
MF:C24H19F2N5O3
MW:463.44
EINECS:
Product Categories:
Mol File:2447686-21-5.mol
Pyrido[3,2-c]pyridazin-3(2H)-one, 4-[4-(difluoromethoxy)phenyl]-6-ethoxy-2-(2-methyl-2H-indazol-5-yl)- Structure
Pyrido[3,2-c]pyridazin-3(2H)-one, 4-[4-(difluoromethoxy)phenyl]-6-ethoxy-2-(2-methyl-2H-indazol-5-yl)- Chemical Properties
Boiling point 599.7±60.0 °C(predicted)
density 1.42±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka1.29±0.20(predicted)
Safety Information
MSDS Information
Pyrido[3,2-c]pyridazin-3(2H)-one, 4-[4-(difluoromethoxy)phenyl]-6-ethoxy-2-(2-methyl-2H-indazol-5-yl)- Usage And Synthesis
UsesMAT2A inhibitor 6 (Compound 3N-h) is a specific MAT2A inhibitor with oral activity and yellow fluorescence (IC50=26 nM), capable of visualizing MAT2A both in vitro and in vivo (λex = 430 nm, λem = 585 nm). MAT2A inhibitor 6 can induce apoptosis and has anticancer activity, which can be used in cancer research[1].
in vivo

MAT2A inhibitor 6 (50 mg/kg; gavage; Once daily for 14 days) inhibits the growth of HCT-116 (MTAP KO) tumor in Balb/c mice with HCT-116 (MTAP KO) tumor and showed antitumor activity[1].

References[1] Wang Z, et al. Computer-aided design of a fluorescent MAT2A inhibitor for visualized cancer synthetic lethality. Bioorg Chem. 2024 Sep;150:107582. DOI:10.1016/j.bioorg.2024.107582
Pyrido[3,2-c]pyridazin-3(2H)-one, 4-[4-(difluoromethoxy)phenyl]-6-ethoxy-2-(2-methyl-2H-indazol-5-yl)- Preparation Products And Raw materials
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