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| | CORTICOTROPIN RELEASING FACTOR ANTAGONIST Basic information |
| | CORTICOTROPIN RELEASING FACTOR ANTAGONIST Chemical Properties |
| storage temp. | Desiccate at -20°C | | solubility | Soluble to 1 mg/ml in 0.1% TFA | | form | Powder | | color | White to off-white |
| | CORTICOTROPIN RELEASING FACTOR ANTAGONIST Usage And Synthesis |
| Uses | α-Helical CRF(9-41) is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) is also a partial agonist of CRF1 receptor with an EC50 of 140 nM[1][2]. | | References | [1] Sonia Tucci, et al. Corticotropin releasing factor antagonist, alpha-helical CRF(9-41), reverses nicotine-induced conditioned, but not unconditioned, anxiety. Psychopharmacology (Berl). 2003 May;167(3):251-6. DOI:10.1007/s00213-003-1403-4
[2] Smart D, et al. Characterisation using microphysiometry of CRF receptor pharmacology. Eur J Pharmacol. 1999 Aug 27;379(2-3):229-35. DOI:10.1016/s0014-2999(99)00506-3 |
| | CORTICOTROPIN RELEASING FACTOR ANTAGONIST Preparation Products And Raw materials |
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