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| | CHEMPACIFIC 38132 Basic information |
| Product Name: | CHEMPACIFIC 38132 | | Synonyms: | CHEMPACIFIC 38132;4-NITRO-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER;METHYL 4-NITRO-PYRIDINE-2-CARBOXYLIATE;4-Nitro-2-pyridinecarboxylic acid methyl ester;Methyl 4-nitro-2-pyridinecarboxylate;2-Pyridinecarboxylic acid, 4-nitro-, Methyl ester;methyl 4-nitropyridine-2-carboxylate;METHYL 4-NITROPICOLINATE | | CAS: | 29681-41-2 | | MF: | C7H6N2O4 | | MW: | 182.13 | | EINECS: | | | Product Categories: | | | Mol File: | 29681-41-2.mol |  |
| | CHEMPACIFIC 38132 Chemical Properties |
| Boiling point | 332.2±22.0 °C(Predicted) | | density | 1.375±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -3.24±0.10(Predicted) |
| | CHEMPACIFIC 38132 Usage And Synthesis |
| Synthesis | General procedure for the synthesis of methyl 4-nitropyridinecarboxylate from methanol and 4-nitro-2-pyridinecarboxylic acid: firstly, esterification of 4-nitro-2-pyridinecarboxylic acid was carried out in anhydrous methanol by reacting with concentrated sulfuric acid as a catalyst at 25 °C for 18 h. Methyl 4-nitropyridinecarboxylate (1f) was obtained in 65% yield. Subsequently, a mixed solution of methyl 4-nitro-2-pyridinecarboxylate (1f) (1.0 g, 6.62 mmol) with acetone (0.195 mL, 2.65 mmol) in DME (5 mL) was slowly added dropwise to a stirred NaH suspension (60% oil suspension, 0.5 g, 13.23 mmol in DME 5 mL), and the reaction was carried out at room temperature under argon protection. The reaction was carried out at room temperature under argon protection. The reaction mixture was stirred at 30 °C for 2 h or 18 h and then refluxed for 2 h, during which no gas escape was observed. The feedstock was recovered during reprocessing. | | References | [1] Tetrahedron, 2014, vol. 70, # 45, p. 8520 - 8531 |
| | CHEMPACIFIC 38132 Preparation Products And Raw materials |
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