(E)-(+/-)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester

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(E)-(+/-)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester Basic information
Product Name:(E)-(+/-)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester
Synonyms:CGP 39551;(E)-(+/-)-2-AMINO-4-METHYL-5-PHOSPHONO-3-PENTENOIC ACID ETHYLESTHER;2-Amino-4-methyl-5-phosphono-3 pentenoic acid carboxyethyl ester;3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, 1-ethyl ester, (3E)-;3-Pentenoic acid, 2-amino-4-methyl-5-phosphono-, 1-ethyl ester, (E)-(+-)-;(E)-(4-Amino-5-ethoxy-2-methyl-5-oxopent-2-en-1-yl)phosphonic acid;CGP 39551, competitive NMDA antagonist;(E)-(+/-)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester
CAS:127910-32-1
MF:C8H16NO5P
MW:237.19
EINECS:
Product Categories:Glutamate receptor;Glutamate
Mol File:127910-32-1.mol
(E)-(+/-)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester Structure
(E)-(+/-)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester Chemical Properties
Boiling point 434.1±55.0 °C(Predicted)
density 1.312±0.06 g/cm3(Predicted)
storage temp. Desiccate at +4°C
solubility H2O: soluble15mg/mL, clear
form powder
pka2.30±0.10(Predicted)
color white to beige
Water Solubility Soluble to 100 mM in water
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45
RIDADR UN 2811 6.1 / PGIII
WGK Germany 3
MSDS Information
(E)-(+/-)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester Usage And Synthesis
UsesCGP 39551 is a potent, selective and competitive NMDA antagonist.
Biological ActivityPotent, selective and competitive NMDA antagonist (K i = 310 nM for inhibition of [ 3 H]-CPP binding in rat brain). Centrally active upon oral administration in vivo .
in vivo

CGP 39551 exhibits maximal electroshock-induced seizures in mice with the ED50 of 4 mg/kg (p.o.)[2].
Following chronic neonatal treatment with CGP 39551, adult rats show increased behavioral responses to the D2 dopamine receptor stimulation[3].

storageDesiccate at +4°C
(E)-(+/-)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester Preparation Products And Raw materials
Tag:(E)-(+/-)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester(127910-32-1) Related Product Information
(E)-(+/-)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester (E)-(+/-)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid 3-Pentenoic acid 3-Pentenoic acid GluN1(356-385)