| Company Name: |
Energy Chemical |
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
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| | Quinoxaline, 6-(chloromethyl)- Basic information |
| | Quinoxaline, 6-(chloromethyl)- Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| | Quinoxaline, 6-(chloromethyl)- Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 6-(chloromethyl)quinoxaline from 6-methylquinoxaline is as follows:
Example 1: Catalytic air dehydrogenation of 6-hydroxymethyl-methyl-quinoxaline
In a 500 mL round-bottomed flask, 6-methylquinoxaline (10 g, 69.4 mmol) was dissolved in 240 g of acetonitrile with N-chlorosuccinimide (14 g, 105.3 mmol). Benzoyl peroxide (0.4 g, 1.65 mmol) was added as initiator. A reflux condenser was installed and the reaction mixture was heated and refluxed for 6 hours, followed by the addition of benzoyl peroxide (0.1 g). The reflux reaction was continued for a total reaction time of 12 hours. Upon completion of the reaction, the reaction solution was analyzed by gas chromatography (GC), which showed the generation of 6-(chloromethyl)quinoxaline with 80% selectivity and 60% conversion. | | References | [1] Patent: US6559308, 2003, B1 |
| | Quinoxaline, 6-(chloromethyl)- Preparation Products And Raw materials |
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