1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile CAS#: 150651-39-1

1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile

生物活性靶点体外研究用途与合成方法 MSDS 1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile价格(试剂级) 上下游产品信息

中文名称	1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
中文同义词	1-氨基-3-(对甲苯基)苯并[4,5]咪唑并[1,2-A]吡啶-2,4-二甲腈;化合物IFSP1;化合物IFSP1,10 MM DMSO 溶液;iFSP1 ,S9663;iFSP1铁死亡诱导剂;iFSP1铁死亡诱导剂
英文名称	1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
英文同义词	1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile;Pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile, 1-amino-3-(4-methylphenyl)-;SW620,Gpx4-knockout,FSP1,Ferroptosis,cancer,FSP1-knockout,iFSP1,iFSP-1,iFSP 1,cell,U-373,A549,RSL3,NCl-H1437,inhibit,Inhibitor;iFSP1, 10 mM in DMSO;13-Amino-11-(4-methylphenyl)-1,8-diazatricyclo[7.4.0.0,2,7]trideca-2,4,6,8,10,12-hexaene-10,12-dicarbonitrile;iFSP1 ，S9663;1-amino-3-(paramethylphenyl)benzenebenzo[4，5]imidazolebenzo[1，2-a]pyridine-2，4-dimethylnitrile;iFSP1
CAS号	150651-39-1
分子式	C20H13N5
分子量	323.35
EINECS号
相关类别	对照品
Mol文件	150651-39-1.mol
结构式

1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile 性质

密度	1.31±0.1 g/cm3(Predicted)
储存条件	Store at -20°C
溶解度	DMSO:30.0(最大浓度 mg/mL);92.78(最大浓度 mM)
形态	结晶固体
酸度系数(pKa)	2.90±0.50(Predicted)
颜色	浅黄至黄色

1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile 用途与合成方法

生物活性

iFSP1 是一种有效的、选择性的且不依赖谷胱甘肽的 ferroptosis suppressor protein 1 (FSP1/AIFM2) 的抑制剂，EC50值为103 nM。iFSP1 可在过表达FSP1的GPX4基因敲除的Pfa1细胞和HT1080细胞中选择性诱导铁死亡。

靶点

Target	Value
FSP1/AIFM2 (Cell-free assay)	103 nM(EC50)

体外研究

iFSP1 (0.001-1 μM; 24 hours) inhibits the Gpx4-knockout cell growth as a dose-dependent manner, but does not inhibit the wild type cell growth. Treatment with the ferroptosis inhibitor Lip-1 protects GPX4- knockout cells from iFSP1-induced ferroptosis.iFSP1 (0.001-1 μM; 24 hours) is less efficient than genetic deletion of FSP1, whereas iFSP1 treatment in the FSP1-knockout background had no additive effect to RSL3-induced ferroptosis.iFSP1 (3 μM; 24 hours) treatment results in an obvious toxicity of RSL3 in a panel of genetically engineered (FSP1-knockout) human cancer cell lines.AIFM2: the flavoprotein apoptosis-inducing factor mitochondria-associated 2 is a previously unrecognized anti-ferroptotic gene. AIFM2, which is renamed ferroptosis suppressor protein 1 (FSP1)

Cell Proliferation Assay

Cell Line:	Wild-type and Gpx4-knockout Pfa1 or HT 1080 cells overexpressing FSP1–HA
Concentration:	0.001-1 μM
Incubation Time:	24 hours
Result:	Was toxic to cells that depend solely (no GPX4 expression detectable) on FSP1 function.

Cell Viability Assay

Cell Line:	NCl-H1437, NCl-H1437 FSP1 KO, U-373, U-373 FSP1 KO, MDA-MB-436, MDA-MB-436 FSP1 KO, SW620, SW620 FSP1 KO, MDA-MB-435S, MDA-MB-435S FSP1 KO, A549 and A549 FSP1 KO
Concentration:	3 μM
Incubation Time:	24 hours
Result:	Sensitized a variety of human cancer cell lines to the ferroptosis inducer (1S,3R)-RSL3.

安全信息

MSDS信息

1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile 价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2026/09/15	HY-136057	iFSP1	150651-39-1	5 mg	300元
2026/09/15	HY-136057	1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile iFSP1	150651-39-1	10mM * 1mLin DMSO	330元

1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile