| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
sales8178@energy-chemical.com |
|
| | Ethyl 4-fluoro-3-nitrobenzoate Basic information |
| | Ethyl 4-fluoro-3-nitrobenzoate Chemical Properties |
| Melting point | 45.3 °C | | Boiling point | 312.3±22.0 °C(Predicted) | | density | 1.333±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | crystalline powder | | color | Pale creamy lemon | | CAS DataBase Reference | 367-80-6(CAS DataBase Reference) |
| | Ethyl 4-fluoro-3-nitrobenzoate Usage And Synthesis |
| Synthesis | Step 1: 5.00 g (27.0 mmol) of 4-fluoro-3-nitrobenzoic acid was dissolved in 50 mL of saturated ethanolic hydrochloric acid solution (1.25 M) and the reaction was refluxed for 15 hours. After completion of the reaction, the reaction mixture was evaporated using a rotary evaporator. Purification by fast column chromatography [silica gel, eluent petroleum ether/ethyl acetate (4:1)] afforded 5.48 g (25.7 mmol, 95%) of ethyl 4-fluoro-3-nitrobenzoate as a colorless solid. Thin layer chromatography (TLC) Rf = 0.48 [silica gel, petroleum ether/ethyl acetate (4:1)]. Mass Spectrometry (ESI) m/z: [M + H]+ calculated value of 214. | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 7, p. 1859 - 1863
[2] Patent: US2007/112033, 2007, A1. Location in patent: Page/Page column 17-18
[3] Patent: US2013/79306, 2013, A1. Location in patent: Paragraph 0226; 0227; 0228; 0229
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 16, p. 7262 - 7272
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 4, p. 1646 - 1663 |
| | Ethyl 4-fluoro-3-nitrobenzoate Preparation Products And Raw materials |
|