| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
5,4'-Dihydroxyflavone manufacturers
|
| | 5,4'-Dihydroxyflavone Basic information |
| Product Name: | 5,4'-Dihydroxyflavone | | Synonyms: | 5-Hydroxy-2-(4-hydroxyphenyl)-4H-chroMen-4-one;5-Hydroxy-2-(4-hydroxyphenyl);4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)-;5-Dihydroxyflavone;Lipoxygenase,Glucosidase,LOX,4',5-Dihydroxyflavone,4',5 Dihydroxyflavone,inhibit,Inhibitor,4',5Dihydroxyflavone;4'',5-Dihydroxyflavone, 10 mM in DMSO;4',5-Dihydroxyflavone;4',5-Dihydroxyflavone | | CAS: | 6665-67-4 | | MF: | C15H10O4 | | MW: | 254.24 | | EINECS: | | | Product Categories: | Di-substituted Flavones | | Mol File: | 6665-67-4.mol |  |
| | 5,4'-Dihydroxyflavone Chemical Properties |
| Melting point | 239-240°C | | Boiling point | 486.0±45.0 °C(Predicted) | | density | 1.443±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 155 mg/mL (609.66 mM);Water : < 0.1 mg/mL (insoluble) | | form | Solid | | pka | 6.78±0.40(Predicted) | | color | Light yellow to yellow |
| | 5,4'-Dihydroxyflavone Usage And Synthesis |
| Uses | 4',5-Dihydroxyflavone is a soybean LOX-1 and yeast α-Glucosidase inhibitor, with an Ki of 102.6 μM for soybean LOX-1 and an IC50 of 66 μM for yeast α-glucosidase. LOX-1 isshort for Lectin-like oxidized low-density lipoprotein receptor-1. | | References | [1] Ribeiro D, et al. Inhibition of LOX by flavonoids: a structure-activity relationship study. Eur J Med Chem. 2014 Jan 24;72:137-45. DOI:10.1016/j.ejmech.2013.11.030
[2] Proena C, et al. α-Glucosidase inhibition by flavonoids: an in vitro and in silico structure-activity relationship study. J Enzyme Inhib Med Chem. 2017 Dec;32(1):1216-1228. DOI:10.1080/14756366.2017.1368503 |
| | 5,4'-Dihydroxyflavone Preparation Products And Raw materials |
|