F 11440
| 中文名称 | F 11440 |
|---|---|
| 中文同义词 | 4-甲基-2- [4- [4-(2-嘧啶基)-1-哌嗪基]丁基] -1,2,4-三嗪-3,5(2H,4H) - 二酮;F 11440游离态;化合物EPTAPIRONE;4-甲基-2-(4-(4-(嘧啶-2-基)哌嗪-1-基)丁基)-1,2,4-三嗪-3,5(2H,4H)-二酮;化合物EPTAPIRONE,10 MM DMSO 溶液;F-11440 (Eptapirone);化合物:Eptapirone (F 11440);Eptapirone 试剂 |
| 英文名称 | EPTAPIRONE |
| 英文同义词 | EPTAPIRONE;4-methyl-2-(4-(4-(pyrimidin-2-yl)piperazin-1-yl)butyl)-1,2,4-triazine-3,5(2H,4H)-dione;F 11440;4-Methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2,4-triazine-3,5(2H,4H)-dione;F-11440;F11440;1,2,4-Triazine-3,5(2H,4H)-dione, 4-methyl-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-;Eptapirone(F11440);Serotonin Receptor,5-HT Receptor,Eptapirone,inhibit,F-11440,5-hydroxytryptamine Receptor,Inhibitor,F11440 |
| CAS号 | 179756-58-2 |
| 分子式 | C16H23N7O2 |
| 分子量 | 345.4 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 179756-58-2.mol |
| 结构式 |  |
F 11440 性质
| 沸点 | 517.4±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.35±0.1 g/cm3(Predicted) |
| 储存条件 | Inert atmosphere,Room Temperature |
| 溶解度 | DMF：10.0（最大浓度 mg/mL）；28.95（最大浓度 mM） |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 7.72±0.10(Predicted) |
| 颜色 | 白色至米白色 |
|
5-HT 1A Receptor
|
The affinity of Eptapirone (F11440) for 5-HT1Abinding sites (pKi, 8.33) was higher than that of buspirone (pKi , 7.50), and somewhat lower than that of flesinoxan (pKi , 8.91).In vivo, Eptapirone (F11440) was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-HT1A agonist activity at pre- and postsynaptic receptors in rats (measured by, for example, its ability to decrease hippocampal extracellular serotonin (5-HT) levels and to increase plasma corticosterone levels, respectively). Eptapirone (F11440), shown here to be a potent, selective, high efficacy 5-HT1Areceptor agonist, appears to have the potential to exert marked anxiolytic and antidepressant activity in humans.[1]
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/07/06 | S0113 | F 11440 Eptapirone | 179756-58-2 | 5mg | 2285.7元 |
| 2026/07/06 | S0113 | F 11440 Eptapirone | 179756-58-2 | 25mg | 6855.53元 |