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| | 4-Fluoro-4-piperidine ethylcarboxylate hydrochloride Basic information |
| Product Name: | 4-Fluoro-4-piperidine ethylcarboxylate hydrochloride | | Synonyms: | Ethyl 4-Fluoropiperidine-4-carboxylate Hydrochloride;Ethyl 4-fluoropiperidine-4-carboxylate, HCl;Ethyl 4-fluoro-4-piperidinecarboxylate hydrochloride;ethyl 4-fluoropiperidin-1-ium-4-carboxylate;4-Piperidinecarboxylic acid, 4-fluoro-, ethyl ester, hydrochloride (1:1);4-fluoro-4-Piperidinecarboxylic acid ethyl ester hydrochloride (1:1);4-Fluoro-4-piperidinecarboxylic acid ethyl ester HCl;4-Fluoro-4-piperidine ethylcarboxylate hydrochloride | | CAS: | 845909-49-1 | | MF: | C8H15ClFNO2 | | MW: | 211.67 | | EINECS: | | | Product Categories: | | | Mol File: | 845909-49-1.mol |  |
| | 4-Fluoro-4-piperidine ethylcarboxylate hydrochloride Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | crystalline solid | | color | White to off-white |
| | 4-Fluoro-4-piperidine ethylcarboxylate hydrochloride Usage And Synthesis |
| Uses | Ethyl 4-fluoropiperidine-4-carboxylate, HCl | | Synthesis | General procedure for the synthesis of ethyl 4-fluoro-4-piperidinecarboxylate hydrochloride from ethyl N-Boc-4-fluoro-4-piperidinecarboxylate: To a solution of tert-butyl 4-chloro-4-tert-butyl-4-fluoro-piperidine-1,4-dicarboxylate (15 g, 54.48 mmol, 1.00 eq.) in methylene chloride (150 mL), a solution of 4 M hydrogen chloride in dioxane (100 mL) was added. The reaction mixture was stirred at 25 °C overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure to afford 11 g (95% yield) of ethyl 4-fluoropiperidine-4-carboxylate hydrochloride as a white solid. | | References | [1] Patent: US2018/79742, 2018, A1. Location in patent: Paragraph 0328; 0329
[2] Patent: US2012/88750, 2012, A1. Location in patent: Page/Page column 34; 35
[3] Patent: US2018/258076, 2018, A1. Location in patent: Paragraph 0506 |
| | 4-Fluoro-4-piperidine ethylcarboxylate hydrochloride Preparation Products And Raw materials |
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