1-[3-Cyano-4-(2,2-dimethyl-propoxy)-phenyl]-1H-pyrazole-4-carboxylic acid

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1-[3-Cyano-4-(2,2-dimethyl-propoxy)-phenyl]-1H-pyrazole-4-carboxylic acid manufacturers

  • Niraxostat
  • Niraxostat pictures
  • $127.00
  • 2026-04-20
  • CAS:206884-98-2
  • Purity: 98.13%
  • Supply Ability: 10g
1-[3-Cyano-4-(2,2-dimethyl-propoxy)-phenyl]-1H-pyrazole-4-carboxylic acid Basic information
Product Name:1-[3-Cyano-4-(2,2-dimethyl-propoxy)-phenyl]-1H-pyrazole-4-carboxylic acid
Synonyms:1H-PYRAZOLE-4-CARBOXYLIC ACID, 1-[3-CYANO-4-(2,2-DIMETHYLPROPOXY)PHENYL]-;PIRAXOSTAT;Y 700;Niraxostat;AETHRPHBGJAIBT-UHFFFAOYSA-N;Y 700 - Piraxostat;1-(3-cyano-4-(neopentyloxy)phenyl)-1H-pyrazole-4-carboxylic acid;Niraxostat, 10 mM in DMSO
CAS:206884-98-2
MF:C16H17N3O3
MW:299.32
EINECS:
Product Categories:
Mol File:206884-98-2.mol
1-[3-Cyano-4-(2,2-dimethyl-propoxy)-phenyl]-1H-pyrazole-4-carboxylic acid Structure
1-[3-Cyano-4-(2,2-dimethyl-propoxy)-phenyl]-1H-pyrazole-4-carboxylic acid Chemical Properties
Boiling point 500.5±45.0 °C(Predicted)
density 1.20±0.1 g/cm3(Predicted)
pka3.68±0.10(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
1-[3-Cyano-4-(2,2-dimethyl-propoxy)-phenyl]-1H-pyrazole-4-carboxylic acid Usage And Synthesis
UsesNiraxostat (Y-700; Piraxostat) is an orally active xanthine oxidoreductase (XOR) inhibitor used in the study of hyperuricemia and other diseases in which XOR may be involved[1].
in vivo

Niraxostat (Y-700; 1 mg/kg) has high oral bioavailability (84.1%) and is almost not excreted through the kidneys. It is mainly eliminated through the liver[1].
Niraxostat (Y- 700; 1-10 mg/kg; oral; single dose) dose-dependently reduces plasma urate levels in oxonate-treated rats [1].
Niraxostat (Y-700 ; 0.3-3 mg/kg; Oral; Single dose) In normal rats, dose-dependently reduces urinary excretion of urate and allantoin while increasing excretion of hypoxanthine and xanthine [1].

Pharmacokinetic Analysis of Niraxostat (Y-700) in normal rats[1]

RouteDose (mg/kg)tmax (h)Cmax (μg/ml)AUC0-∞ (μg/h/ml)t1/2 (h)
PO0.30.50.432.075.0
PO10.31.87.013.2
PO30.56.4930.312.7
IV1/3.978.342.5
References[1] Fukunari A, et al. Y-700 [1-[3-Cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid]: a potent xanthine oxidoreductase inhibitor with hepatic excretion. J Pharmacol Exp Ther. 2004 Nov;311(2):519-28. DOI:10.1124/jpet.104.070433
1-[3-Cyano-4-(2,2-dimethyl-propoxy)-phenyl]-1H-pyrazole-4-carboxylic acid Preparation Products And Raw materials
Tag:1-[3-Cyano-4-(2,2-dimethyl-propoxy)-phenyl]-1H-pyrazole-4-carboxylic acid(206884-98-2) Related Product Information
5-amino-2-ethoxybenzonitrile Benzonitrile, 5-amino-2-methoxy- (9CI) 3-(1H-Pyrazol-1-yl)benzonitrile 1-[3-Cyano-4-(2,2-dimethyl-propoxy)-phenyl]-1H-pyrazole-4-carboxylic acid 5-Amino-2-hydroxybenzonitrile 1-(4-Methoxyphenyl)-1H-pyrazole-4-carboxylic acid