| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:Parstatin (Mouse)
CAS:1065756-01-5
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | Parstatin (mouse) Basic information |
| Product Name: | Parstatin (mouse) | | Synonyms: | Parstatin (mouse);MGPRRLLIVALGLSLCGPLLSSRVPMSQPESERTDATVNPR;Parstatin (mouse) TFA | | CAS: | 1065756-01-5 | | MF: | C189H326N58O57S3 | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Parstatin (mouse) Structure]() |
| | Parstatin (mouse) Chemical Properties |
| storage temp. | Store at -20°C | | form | Powder | | color | White to off-white | | Water Solubility | Soluble to 1 mg/ml in water |
| | Parstatin (mouse) Usage And Synthesis |
| Description | Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50~ 20μM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apoptotic activityin vitro. Inhibits angiogenesis and exhibits cardioprotective activityin vivo. | | Uses | Parstatin(mouse), a cell-penetrating PAR-1 thrombin receptor agonist peptide, is a potent inhibitor of angiogenesis[1][2]. | | in vivo | Parstatin (single dose, 1-25 μg/kg, iv) administered prior to ischaemia confers immediate cardioprotection by recruiting the Gi-protein activation pathway including p38 MAPK, ERK1/2, NOS, and KATP channels. Parstatin exerts effects on both the cardiomyocytes and the coronary circulation to induce cardioprotection. This suggests a potential therapeutic role of parstatin in the treatment of cardiac injury resulting from ischaemia and reperfusion[1]. | Animal Model: | Male Sprague–Dawley rats at 8 weeks of age (250-300 g)[1]. | | Dosage: | 1-25 μg/kg. | | Administration: | IV injected 15 min prior to ischaemia. | | Result: | A significant decrease in infarct size was detected with the 5-15 μg/kg doses with 10 μg/kg as the optimal dose. These hearts had an infarct size of 46 ± 3% of the area at risk, which is a 26% reduction in infarct size compared with the control. |
| | References | [1] Panagiota Zania, et al. Parstatin, the Cleaved Peptide on Proteinase-Activated Receptor 1 Activation, Is a Potent Inhibitor of Angiogenesis. J Pharmacol Exp Ther. 2009 Feb;328(2):378-89. DOI:10.1124/jpet.108.145664
[2] Jennifer L Strande, et al. Parstatin: A Cryptic Peptide Involved in Cardioprotection After Ischaemia and Reperfusion Injury. Cardiovasc Res. 2009 Jul 15;83(2):325-34. DOI:10.1093/cvr/cvp122 |
| | Parstatin (mouse) Preparation Products And Raw materials |
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