5-Bromo-2-hydroxybenzonitrile

5-Bromo-2-hydroxybenzonitrile Suppliers list

Company Name:	Shanghai Harvest Chemical Industrial Co., Ltd. Gold
Tel:	15721252604 17321035817
Email:	sales@harvest-chem.com

Company Name:	TCI (Shanghai) Development Co., Ltd.
Tel:	021-67121386
Email:	Sales-CN@TCIchemicals.com

5-Bromo-2-hydroxybenzonitrile manufacturers

5-Bromo-2-hydroxybenzonitrile Basic information

Product Name:	5-Bromo-2-hydroxybenzonitrile
Synonyms:	BUTTPARK 20\02-76;4-BROMO-2-CYANOPHENOL;5-BROMOSALICYLONITRILE;AKOS BBS-00003099;2-HYDROXY-5-BROMOBENZONITRILE;4-Bromo-2-cyanophenol 2-Hydroxy-5-bromobenzonitrile;4-Bromo-2-cyanophenol, 5-Bromosalicylonitrile;Benzonitrile,5-broMo-2-hydroxy-
CAS:	40530-18-5
MF:	C7H4BrNO
MW:	198.02
EINECS:	254-958-1
Product Categories:	Building Blocks;C6 to C7;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Aromatic Nitriles;Nitrile;Bromine Compounds;Nitriles;Phenols;C6 to C7;Cyanides/Nitriles;Nitrogen Compounds
Mol File:	40530-18-5.mol

5-Bromo-2-hydroxybenzonitrile Chemical Properties

Melting point	158-163 °C
Boiling point	282.8±25.0 °C(Predicted)
density	1.79
storage temp.	Inert atmosphere,Room Temperature
solubility	slightly sol. in Methanol
pka	6.60±0.18(Predicted)
form	powder to crystal
color	White to Light yellow
InChI	InChI=1S/C7H4BrNO/c8-6-1-2-7(10)5(3-6)4-9/h1-3,10H
InChIKey	PVCONXMDUZOPJH-UHFFFAOYSA-N
SMILES	C(#N)C1=CC(Br)=CC=C1O
CAS DataBase Reference	40530-18-5(CAS DataBase Reference)

Safety Information

MSDS Information

5-Bromo-2-hydroxybenzonitrile Usage And Synthesis

Chemical Properties	Off-white crystalline
Synthesis	1761-61-1 40530-18-5 Synthesis of 5-bromo-2-hydroxybenzonitrile: To a solution of 5-bromosalicylaldehyde (80.0 g, 0.40 mol) in formic acid was added hydroxylamine hydrochloride (36.0 g, 0.52 mol) and sodium form (37.0 g, 0.52 mol) in sequence. The reaction mixture was stirred at 100 °C for 7 hours. After completion of the reaction, the solvent was removed by evaporation and the residue obtained was dissolved in ethyl acetate. The organic layer was washed with water and dried. The solvent was again removed by evaporation and petroleum ether was added to the residue, and the precipitated crystals were filtered to give 5-bromo-2-hydroxybenzonitrile (75.2 g, 95% yield).1H-NMR (DMSO-d6) δ: 6.98 (d, J = 8.9 Hz, 1H), 7.65 (dd, J = 8.9,2.4 Hz, 1H), 7.86 (d, J = 2.4 Hz , 1H), 11.41 (s, 1H).
References	[1] Patent: EP2128136, 2009, A1. Location in patent: Page/Page column 7 [2] Heterocyclic Communications, 2009, vol. 15, # 5, p. 335 - 341 [3] Indian Journal of Heterocyclic Chemistry, 2010, vol. 20, # 2, p. 129 - 132 [4] Synthetic Communications, 1992, vol. 22, # 14, p. 2125 - 2128 [5] New Journal of Chemistry, 2000, vol. 24, # 7, p. 541 - 546

5-Bromo-2-hydroxybenzonitrile Preparation Products And Raw materials

Raw materials	5-Bromosalicylaldehyde-->5-Bromo-2-hydroxybenzaldehyde oxime
Preparation Products	2-(tetrahydro-2H-pyran-4-yloxy)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzonitrile-->D0128-->5-broMo-2-(tetrahydro-2H-pyran-4-yloxy)benzonitrile-->3-Amino-5-bromo-benzofuran-2-carboxylic acid ethyl ester

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