4-CYANO-N-[2-(CYCLOHEX-1-EN-1-YL)-4-{1-[2-(DIMETHYLAMINO)ACETYL]PIPERIDIN-4-YL}PHENYL]-1H-IMIDAZOLE-2-CARBOXAMIDE
| 中文名称 | 4-CYANO-N-[2-(CYCLOHEX-1-EN-1-YL)-4-{1-[2-(DIMETHYLAMINO)ACETYL]PIPERIDIN-4-YL}PHENYL]-1H-IMIDAZOLE-2-CARBOXAMIDE |
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| 中文同义词 | 化合物 T21330;化合物 JNJ-28312141 |
| 英文名称 | JNJ-28312141 |
| 英文同义词 | CS-2012;JNJ-28312141; JNJ28312141; JNJ 28312141.;JNJ 28312141; JNJ28312141;JNJ-28312141;JNJ-28312141(JNJ-141);4-Cyano-N-(5-(1-(2-(dimethylamino)acetyl)piperidin-4-yl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl;4-CYANO-N-[2-(CYCLOHEX-1-EN-1-YL)-4-{1-[2-(DIMETHYLAMINO)ACETYL]PIPERIDIN-4-YL}PHENYL]-1H-IMIDAZOLE-2-CARBOXAMIDE;1H-Imidazole-2-carboxamide, 5-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[2-(dimethylamino)acetyl]-4-piperidinyl]phenyl]- |
| CAS号 | 885692-52-4 |
| 分子式 | C26H32N6O2 |
| 分子量 | 460.57 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 885692-52-4.mol |
| 结构式 | ![4-CYANO-N-[2-(CYCLOHEX-1-EN-1-YL)-4-{1-[2-(DIMETHYLAMINO)ACETYL]PIPERIDIN-4-YL}PHENYL]-1H-IMIDAZOLE-2-CARBOXAMIDE 结构式](CAS/GIF/885692-52-4.gif) |
4-CYANO-N-[2-(CYCLOHEX-1-EN-1-YL)-4-{1-[2-(DIMETHYLAMINO)ACETYL]PIPERIDIN-4-YL}PHENYL]-1H-IMIDAZOLE-2-CARBOXAMIDE 性质
| 密度 | 1.27±0.1 g/cm3(Predicted) |
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| 形态 | 白色粉末 |
| 酸度系数(pKa) | 7.30±0.10(Predicted) |
4-CYANO-N-[2-(CYCLOHEX-1-EN-1-YL)-4-{1-[2-(DIMETHYLAMINO)ACETYL]PIPERIDIN-4-YL}PHENYL]-1H-IMIDAZOLE-2-CARBOXAMIDE 用途与合成方法
JNJ-28312141 是一种集落刺激因子 1 受体 (CSF-1R 或 FMS) 抑制剂，IC50 为 0.69 nM。JNJ-28312141 可抑制 BDBM，MV-4-11，M-o7e 和 TF-1 细胞增殖，IC50 为 2.6，21，41 和 150 nM。JNJ-28312141 在小鼠关节炎模型中表现出抗炎活性。