- BPTU
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- $32.00
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2026-06-02
- CAS:870544-59-5
- Purity: 99.51%
- Supply Ability: 10g
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| | Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- Basic information |
| Product Name: | Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- | | Synonyms: | Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]-;1-(2-(2-(tert-butyl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea;N-[2-[2-(1,1-Dimethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoromethoxy)phenyl]urea;CS-2758;BMS-646786;BPTU,antithrombotic,thrombosis,BMS 646786,P2Y Receptor,inhibit,BMS646786,Inhibitor;BPTU, 10 mM in DMSO;P2Y Antagonist II, BPTU | | CAS: | 870544-59-5 | | MF: | C23H22F3N3O3 | | MW: | 445.43 | | EINECS: | | | Product Categories: | API | | Mol File: | 870544-59-5.mol | ![Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- Structure](CAS/20150408/GIF/870544-59-5.gif) |
| | Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- Chemical Properties |
| Boiling point | 426.3±45.0 °C(Predicted) | | density | 1.307±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:34.29(Max Conc. mg/mL);76.98(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.67(Max Conc. mM)
DMF:15.0(Max Conc. mg/mL);33.67(Max Conc. mM)
Ethanol:29.77(Max Conc. mg/mL);66.83(Max Conc. mM) | | form | A solid | | pka | 12.59±0.70(Predicted) | | color | White to off-white | | InChI | 1S/C23H22F3N3O3/c1-22(2,3)17-7-4-5-9-19(17)31-20-18(8-6-14-27-20)29-21(30)28-15-10-12-16(13-11-15)32-23(24,25)26/h4-14H,1-3H3,(H2,28,29,30) | | InChIKey | AHFLGPTXSIRAQK-UHFFFAOYSA-N | | SMILES | FC(F)(F)Oc1ccc(cc1)NC(=O)Nc2c(nccc2)Oc3c(cccc3)C(C)(C)C |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- Usage And Synthesis |
| Uses | BPTU is a non-nucleotide antagonist of P2Y1 receptor. It blocks nerve mediated inhibitory neuromuscular responses in the gastrointestinal tract of rodents. | | Biological Activity | Primary Target
P2Y1', 'Reversible: yes | | in vivo | Uptake of BPTU from the peritoneal cavity is relatively rapid. Blood boron levels are maximal within 1 h after administration. After only 1 h, a boron tumor-to-blood ratio above 1 is found for BPTU in pigmented tumors, which is indicative of drug retention. This is not seen in the non-pigmented tumor variant, in which tumor boron levels closely follow blood levels. Up to 24 h, Borocaptate sodium (BSH) exhibits no selective retention in either tumor, but achieves higher maximum tumor boron concentrations than BPTU as a result of the administration of higher amounts of boron. During the tissue distribution phase, liver-to-kidney boron concentration ratios range from 2 to 4 for BSH and from 0.5 to 1 for BPTU[2]. | | IC 50 | P2Y1 Receptor | | storage | Store at RT |
| | Urea, N-[2-[2-(1,1-diMethylethyl)phenoxy]-3-pyridinyl]-N'-[4-(trifluoroMethoxy)phenyl]- Preparation Products And Raw materials |
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