8-OH-脱氧鸟嘌呤
| 中文名称 | 8-OH-脱氧鸟嘌呤 |
|---|---|
| 中文同义词 | 8-OH-脱氧鸟嘌呤;8-羟基-2'-脱氧鸟嘌呤;2'-脱氧-7,8-二氢-8-氧代鸟苷;8-羟基-2-脱氧鸟苷;8-羟基脱氧鸟苷;2'-脱氧-8-氧代鸟嘌呤;8-氧-2'-脱氧鸟苷;核酸氧化8-羟基脱氧鸟苷 |
| 英文名称 | 8-Oxo-2'-deoxyguanosine |
| 英文同义词 | 2'-Deoxy-8-oxoguanosine;7,8-Dihydro-8-oxo-2'-deoxyguanosine;8-Oxo-7,8-dihydro-2'-deoxyguanosine;8-Oxo-7,8-dihydrodeoxyguanosine;2'-Deoxy-8-oxo-D-guanosine;8-Oxo-7,8-dihydro-2μ-deoxyguanosine, 8-Oxo-dG;2'-Deoxy-8-hydroxyguanosine;8-Oxodeoxyguanosine |
| CAS号 | 88847-89-6 |
| 分子式 | C10H13N5O5 |
| 分子量 | 283.24 |
| EINECS号 | |
| 相关类别 | 合成;Bases & Related Reagents;Labeling and Diagnostics Reagents;Nucleotides;Heterocycles |
| Mol文件 | 88847-89-6.mol |
| 结构式 |  |
8-OH-脱氧鸟嘌呤 性质
| 熔点 | 217-220°C |
|---|---|
| 密度 | 2.25±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 溶于DMSO（高达10mg/ml）。 |
| 形态 | 白色至类白色固体。 |
| 酸度系数(pKa) | 7.86±0.20(Predicted) |
| 颜色 | 米白色 |
| 稳定性 | DMSO中的溶液可在-20°下稳定储存1个月。 |
| InChI | InChI=1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)/t3-,4+,5+/m0/s1 |
| InChIKey | HCAJQHYUCKICQH-VPENINKCSA-N |
| SMILES | OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)NC2=O)C[C@@H]1O |
8-Hydroxy-2'-deoxyguanosine 是氧化应激和致癌反应的关键生物标志物。
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Human Endogenous Metabolite
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8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a good biomarker for risk assessment of various cancers and degenerative diseases. The biomarker 8-Hydroxy-2'-deoxyguanosine (8-OHdG) or 8-oxodG has been a pivotal marker for measuring the effect of endogenous oxidative damage to DNA and as a factor of initiation and promotion of carcinogenesis. The biomarker has been used to estimate the DNA damage in humans after exposure to cancer-causing agents, such as tobacco smoke, asbestos fibers, heavy metals, and polycyclic aromatic hydrocarbons.
安全信息
| 安全说明 | 24/25 |
|---|---|
| WGK Germany | 3 |
| RTECS号 | MF8782675 |
| 海关编码 | 29349990 |
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-W011540R | 8-OH-脱氧鸟嘌呤 8-Hydroxy-2'-deoxyguanosine (Standard) | 88847-89-6 | 1 mg | 1400元 |
| 2026/06/05 | HY-W011540R | 8-OH-脱氧鸟嘌呤 8-Hydroxy-2'-deoxyguanosine (Standard) | 88847-89-6 | 5 mg | 3504元 |