2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione

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2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione manufacturers

  • C527
  • C527 pictures
  • $29.00
  • 2026-07-27
  • CAS:192718-06-2
  • Purity: 97.64%
  • Supply Ability: 10g
  • C527
  • C527 pictures
  • $29.00
  • 2026-07-27
  • CAS:192718-06-2
  • Purity: 97.64%
  • Supply Ability: 10g
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Basic information
Product Name:2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
Synonyms:2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione;2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione;C527;Naphth[2,3-d]oxazole-4,9-dione, 2-(4-fluorophenyl)-;C527 >=98% (HPLC);Inhibitor,C 527,DUBs,C527,Deubiquitinase,C-527,inhibit;2-(4-Fluorophenyl)phtho[2,3-d]oxazole-4,9-dione
CAS:192718-06-2
MF:C17H8FNO3
MW:293.25
EINECS:
Product Categories:
Mol File:192718-06-2.mol
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Structure
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Chemical Properties
Boiling point 488.6±47.0 °C(Predicted)
density 1.433±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO: soluble0.3mg/mL, clear (warmed)
pka-4.21±0.20(Predicted)
form powder
color faint yellow to dark yellow
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 46
WGK Germany 3
MSDS Information
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Usage And Synthesis
UsesC527 is a is a pan DUB enzyme inhibitor, with a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
Biological ActivityC527 is a pan-DUB enzyme inhibitor with high activity against USP1/UAF1 complex with IC50 value of 0.88 μM.
in vitro

Pretreatment of USP1/UAF1 with C527 resulted in inhibition of its enzyme activity with an IC 50 of 0.88±0.03 μM. C527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro . However, the IC 50 of C527 for these DUB enzymes was higher in comparison with USP1/UAF1 complex. C527 has considerably less inhibitory effect on UCH-L1 and UCH-L3, a different subclass of DUB enzymes. C527 treatments causes an increase in the levels of Ub-FANCD2 and Ub-FANCI. Pretreatment of cells with the C527 causes an enhancement in the cytoxicity of mitomycin C and camptothecin. C527 treatments lead to an increase in ubiquitinated forms of FANCD2 and FANCI, cause a decrease in homologous recombination activity, and sensitize cells to DNA damaging agents.

target

0.88 μM (USP1)

References[1] Mistry H, et al. Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther. 2013 Dec;12(12):2651-62. DOI:10.1158/1535-7163.MCT-13-0103-T
2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Preparation Products And Raw materials
Tag:2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione(192718-06-2) Related Product Information
SZL P1-41 ML-323 ML364 methyl ((1S,2R,3S,4R)-2,3-dihydroxy-4-((2-(3-((trifluoromethyl)thio)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)cyclopentyl)sulfamate VLX1570 UCHL1 Protein, Rat (His)