| Company Name: |
BePharm Ltd |
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400-685-9117 |
| Email: |
market@bepharm.com |
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| | Benzofuro[3,2-d]pyriMidine-2,4(1H,3H)-dione Basic information |
| Product Name: | Benzofuro[3,2-d]pyriMidine-2,4(1H,3H)-dione | | Synonyms: | Benzofuro[3,2-d]pyriMidine-2,4(1H,3H)-dione;1H-Benzo[4,5]furo[3,2-D]pyrimidine-2,4-dione;1H-[1]benzofuro[3,2-d]pyrimidine-2,4-dione;BNZOFURO[3,2-D]PYRIMIDINE-2,4(1H,3H)-DIONE | | CAS: | 62208-68-8 | | MF: | C10H6N2O3 | | MW: | 202.17 | | EINECS: | | | Product Categories: | | | Mol File: | 62208-68-8.mol | ![Benzofuro[3,2-d]pyriMidine-2,4(1H,3H)-dione Structure](CAS/20150408/GIF/62208-68-8.gif) |
| | Benzofuro[3,2-d]pyriMidine-2,4(1H,3H)-dione Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature | | Appearance | Off-white to light yellow Solid |
| | Benzofuro[3,2-d]pyriMidine-2,4(1H,3H)-dione Usage And Synthesis |
| Synthesis | Ethyl 2-carbamoylbenzofuran-3-ylcarbamate (114 mg, 0.460 mmol, 1.0 eq.) was heated to reflux for 1 h in 5% NaOH solution (3.7 mL, 4.60 mmol, 10.0 eq.) and EtOH (2.2 mL). Upon completion of the reaction, the mixture was cooled to room temperature and the product was precipitated by addition of 37% HCl solution. The solid was collected by filtration and washed sequentially with water and ether. The resulting benzofuro[3,2-d]pyrimidine-2,4(1H,3H)-dione (40 mg, 43% yield) could be used in the next step of the reaction without further purification. The product was characterized as follows: 1H-NMR (500 MHz, DMSO): δ 12.03 (s, 1H), 11.43 (s, 1H), 8.00 (d, 3JHH = 7.3 Hz, 1H), 7.75 (d, 3JHH = 8.5 Hz, 1H), 7.64 (t, 3JHH = 7.3 Hz, 1H), 7.45 (t, 3JHH = 7.3 Hz, 1H), 7.45 (t, 3JHH = 7.3 Hz). 3JHH = 7.3 Hz, 1H); 13C-NMR (100 MHz, DMSO): δ 155.5, 154.9, 151.3, 133.3, 130.6, 129.8, 123.9, 121.6, 117.6, 112.9. | | References | [1] Patent: WO2010/52569, 2010, A2. Location in patent: Page/Page column 242 |
| | Benzofuro[3,2-d]pyriMidine-2,4(1H,3H)-dione Preparation Products And Raw materials |
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