3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one

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3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one manufacturers

  • IMS2186
  • IMS2186 pictures
  • $41.00
  • 2026-07-27
  • CAS:1031206-36-6
  • Purity: 99.96%
  • Supply Ability: 10g
3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one Basic information
Product Name:3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one
Synonyms:3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one;IMS2186;4H-1-Benzopyran-4-one, 2,3-dihydro-3-[(3-hydroxy-4-methoxyphenyl)methylene]-6-methyl-, (3E)-;(E)-3-(3-Hydroxy-4-methoxybenzylidene)-6-methylchroman-4-one;(3E)-2,3-Dihydro-3-[(3-Hydroxy-4-Methoxyphenyl)Methylene]-6-Methyl-4H-1-Benzopyran-4-One;IMS2186, 10 mM in DMSO;UDP-GlcNAz disodium
CAS:1031206-36-6
MF:C18H16O4
MW:296.32
EINECS:
Product Categories:
Mol File:1031206-36-6.mol
3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one Structure
3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one Chemical Properties
Boiling point 535.7±50.0 °C(Predicted)
density 1.286±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: >20mg/mL
pka9.39±0.10(Predicted)
form solid
color white to off-white
InChI1S/C18H16O4/c1-11-3-5-16-14(7-11)18(20)13(10-22-16)8-12-4-6-17(21-2)15(19)9-12/h3-9,19H,10H2,1-2H3/b13-8+
InChIKeyBZCADTHMZLYKAR-MDWZMJQESA-N
SMILESCOc1ccc(cc1O)\C=C2/COc3ccc(C)cc3C2=O
Safety Information
Hazard Codes N
Risk Statements 50/53
Safety Statements 60-61
RIDADR UN 3077 9 / PGIII
WGK Germany 3
Storage Class11 - Combustible Solids
Hazard ClassificationsAquatic Acute 1
Aquatic Chronic 1
MSDS Information
3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one Usage And Synthesis
UsesIMS2186 is an anti-prileferative and anti-angiogenic compound.
Biological ActivityIMS2186 is an anti-proliferative and anti-angiogenic agent. Apparently IMS2186 blocks the cell cycle at G2 and inhibits the production of PGE2/TNF-α. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC50 = 0.1 μM) and cell migration. Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss.
in vivo

IMS2186 (2.5 mg in 0.5 mL; intravitreal injection; single dose) has no ocular toxicity while applied to rabbit eyes[1].
IMS2186 (100 μg/eye, i.e. 2.0 μL of the solution of 50 μg/μL; single dose) shows anti-proliferative effect on laser-induced choroidal neovascularization (CNV) rat models[1].

Animal Model:Rat model of laser induced CNV[1]
Dosage:100 μg/eye, 2.0 μL of the solution of 50 μg/μL
Administration:Intravitreal injection; single dose
Result:Resulted 30% reduction of lesion area compared to PBS in the lesion area measurement.
3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one Preparation Products And Raw materials
Tag:3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one(1031206-36-6) Related Product Information
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