食欲肽B
| 中文名称 | 食欲肽B |
|---|---|
| 中文同义词 | 食欲肽B (人) ≥97%;食欲肽B;食欲肽B (老鼠) ≥97%, ≥97% (HPLC);食欲肽B (老鼠);食欲肽B (老鼠) ≥97%;OREXIN B, RAT, MOUSE|食欲肽B;食欲肽B (鼠);OREXIN B (MOUSE)|||RAT OREXIN B |
| 英文名称 | H-ARG-PRO-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-ASN-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2 |
| 英文同义词 | ARG-PRO-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-ASN-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2;HYPOCRETIN-B, MOUSE;H-ARG-PRO-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-ASN-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2;OREXIN B (MOUSE);OREXIN B (MOUSE, RAT);OREXIN B (RAT, MOUSE);OREXINS OREXIN B RAT, MOUSE;RPGPPGLQGRLQRLLQANGNHAAGILTM-NH2 |
| CAS号 | 202801-92-1 |
| 分子式 | C126H215N45O34S |
| 分子量 | 2936.4 |
| EINECS号 | |
| 相关类别 | 生化试剂;多肽;其他生化试剂;标准品;Orexin receptor;Peptide |
| Mol文件 | 202801-92-1.mol |
| 结构式 |  |
食欲肽B 性质
| 密度 | 1.49±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | −20°C |
| 溶解度 | 溶于1%醋酸，浓度为1mg/ml |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| 水溶解性 | Soluble in water (1 mg/ml) |
| 序列 | Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 |
Ki: 420 nM (OX1), 36 nM (OX2)
Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC 50 of 36 nM in the binding assay and an EC 50 of 60 nM in the [Ca 2+ ]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC 50 in the competitive binding assay and the EC 50 in the [Ca 2+ ]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively.
Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively.
安全信息
| WGK Germany | 3 |
|---|
| 提供商 | 语言 |
|---|---|
|
英文
|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-P1349 | 食欲肽B Orexin B, rat, mouse | 202801-92-1 | 1mg | 1100元 |
| 2025/12/22 | HY-P1349 | 食欲肽B Orexin B, rat, mouse | 202801-92-1 | 5mg | 2750元 |