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| | DC4 Crosslinker Basic information |
| Product Name: | DC4 Crosslinker | | Synonyms: | DC4 Crosslinker;AJWAJFDEYIAPKX-UHFFFAOYSA-L;1,4-bis[4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxobutyl]-1,4-diazoniabicyclo[2.2.2]octane,dibromide;(2,5-Dioxopyrrolidin-1-yl) 4-[4-[4-(2,5-dioxopyrrolidin-1-yl)oxy-4-oxobutyl]-1,4-diazoniabicyclo[2.2.2]octan-1-yl]butanoate, dibromi de | | CAS: | 1374647-94-5 | | MF: | C22H32Br2N4O8 | | MW: | 640.319 | | EINECS: | | | Product Categories: | | | Mol File: | 1374647-94-5.mol |  |
| | DC4 Crosslinker Chemical Properties |
| solubility | DMSO: 11 mg/ml; PBS (pH 7.2): 3 mg/ml | | form | A crystalline solid | | color | White to off-white |
| | DC4 Crosslinker Usage And Synthesis |
| Description | DC4 crosslinker is a mass spectrometry-cleavable crosslinking reagent (18 in length) that contains two intrinsic positive charges, which allow cross-linked peptides to fragment into their component peptides by collision-induced dissociation or in-source decay.1 Initial fragmentation events result in cleavage on either side of the positive charges so that cross-linked peptides can be identified as pairs of ions separated by defined masses.1 Additionally, these two intact peptide fragments can be further fragmented to yield a series of b- and y-ions for peptide identification.1 | | Uses | DC4 Crosslinker is a stable crosslinking reagent with improved activity and solubility. DC4 Crosslinker is labile cleavable with collision-induced dissociation (CID), that will be fragmented into four rearrange products containing mobilized protons[1]. | | References | 1. Clifford-Nunn, B., Showalter, H.D., and Andrews, P.C. Quaternary diamines as mass spectrometry cleavable crosslinkers for protein interactions J. Am. Soc. Mass Spectrom. 23(2),201-212(2012). |
| | DC4 Crosslinker Preparation Products And Raw materials |
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