| Company Name: |
SPIRO PHARMA |
| Tel: |
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| Email: |
eric_feng1954@126.com |
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| | N1-(4-Butyl-2-methylphenyl)acetamide Basic information |
| Product Name: | N1-(4-Butyl-2-methylphenyl)acetamide | | Synonyms: | 4-N-BUTYL-2-METHYLACETANILIDE;SMIP 004;SMIP004;SMIP-004;4'-(But-1-yl)-2'-methylacetanilide;N-[4-(But-1-yl)-2-methylphenyl]acetamide, 2-Acetamido-5-(but-1-yl)toluene;N-(4-Butyl-2-methylphenyl)acetamide;SMIP 004; SMIP-004 | | CAS: | 143360-00-3 | | MF: | C13H19NO | | MW: | 205.3 | | EINECS: | | | Product Categories: | | | Mol File: | 143360-00-3.mol |  |
| | N1-(4-Butyl-2-methylphenyl)acetamide Chemical Properties |
| Boiling point | 343.0±21.0 °C(Predicted) | | density | 1.003±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≥ 20.5 mg/mL in DMSO, ≥ 53.6 mg/mL in EtOH with ultrasonic | | pka | 15.14±0.70(Predicted) | | form | Solid | | color | White to off-white | | InChI | 1S/C13H19NO/c1-4-5-6-12-7-8-13(10(2)9-12)14-11(3)15/h7-9H,4-6H2,1-3H3,(H,14,15) | | InChIKey | ZFVMECVBUGMWIX-UHFFFAOYSA-N | | SMILES | N(c1c(cc(cc1)CCCC)C)C(=O)C |
| WGK Germany | WGK 2 | | HS Code | 2924297099 | | Storage Class | 11 - Combustible Solids |
| | N1-(4-Butyl-2-methylphenyl)acetamide Usage And Synthesis |
| Uses | SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells[1][2]. | | Biological Activity | Cell permeable: yes', 'Reversible: yes | | in vivo | SMIP004 potently inhibits the growth of prostate and breast cancer xenografts in SCID mice[2]. | | storage | Store at -20°C | | References | [1] Li C, et al. SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination. J Exp Clin Cancer Res. 2019 Feb 13;38(1):76. DOI:10.1186/s13046-019-1069-3
[2] Rico-Bautista E, Zhu W, Kitada S, Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via UPR Signaling. Oncotarget. 2013 Jul 14. DOI:10.18632/oncotarget.1130 |
| | N1-(4-Butyl-2-methylphenyl)acetamide Preparation Products And Raw materials |
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