Carbamic acid, [4(S)-(hydroxymethyl)-2-cyclopenten-1-yl]-1,1-dimethylethyl ester, (1R-cis)-

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Carbamic acid, [4(S)-(hydroxymethyl)-2-cyclopenten-1-yl]-1,1-dimethylethyl ester, (1R-cis)- Basic information
Product Name:Carbamic acid, [4(S)-(hydroxymethyl)-2-cyclopenten-1-yl]-1,1-dimethylethyl ester, (1R-cis)-
Synonyms:TERT-BUTYL CIS-[4(S)-(HYDROXYMETHYL)CYCLOPENT-2-EN-1(R)-YL]CARBAMATE;(1R,4S)-N-(tert-Butyloxycarbonyl)-1-amino-4-(hydroxymethyl)-2-cyclopentene;1-((1R,4S)-4-(Hydroxymethyl)cyclopent-2-en-1-yl)-2-methylpropan-2-yl carbamate;Carbamic acid, [(1R,4S)-4-(hydroxymethyl)-2-cyclopenten-1-yl]-, 1,1-;TERT-BUTYL (1R,4S)-4-(HYDROXYMETHYL)CYCLOPENT-2-ENYLCARBAMATE;tert-Butyl ((1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)carbamate;N-[(1R,4S)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]-carbamic Acid 1,1-Dimethylethyl Ester;Carbamic acid, N-[(1R,4S)-4-(hydroxymethyl)-2-cyclopenten-1-yl]-, 1,1-dimethylethyl ester
CAS:168960-18-7
MF:C11H19NO3
MW:213.27
EINECS:
Product Categories:N-BOC
Mol File:168960-18-7.mol
Carbamic acid, [4(S)-(hydroxymethyl)-2-cyclopenten-1-yl]-1,1-dimethylethyl ester, (1R-cis)- Structure
Carbamic acid, [4(S)-(hydroxymethyl)-2-cyclopenten-1-yl]-1,1-dimethylethyl ester, (1R-cis)- Chemical Properties
Boiling point 338.8±31.0 °C(Predicted)
density 1.09±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO; Methanol
pka12.06±0.40(Predicted)
form Oil
color Yellow
Safety Information
MSDS Information
Carbamic acid, [4(S)-(hydroxymethyl)-2-cyclopenten-1-yl]-1,1-dimethylethyl ester, (1R-cis)- Usage And Synthesis
UsesN-[(1R,4S)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]-carbamic Acid 1,1-Dimethylethyl Ester is an intermediate in synthesizing ent-Abacavir (Abacavir EP Impurity A) (A105015), an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Carbamic acid, [4(S)-(hydroxymethyl)-2-cyclopenten-1-yl]-1,1-dimethylethyl ester, (1R-cis)- Preparation Products And Raw materials
Preparation Products(1S-cis)-4-Amino-2-cyclopentene-1-methanol
Tag:Carbamic acid, [4(S)-(hydroxymethyl)-2-cyclopenten-1-yl]-1,1-dimethylethyl ester, (1R-cis)-(168960-18-7) Related Product Information
1-N-Boc-amino-2-cyclopentene Carbamic acid, [4(S)-(hydroxymethyl)-2-cyclopenten-1-yl]-1,1-dimethylethyl ester, (1R-cis)- (-)-(1S,4R)-N-Boc-4-aminocyclopent-2-enecarboxylic acid tert-Butyl N-allylcarbamate Carbamic acid, 4-pentenyl-, 1,1-dimethylethyl ester (9CI) (1S-cis)-4-Amino-2-cyclopentene-1-methanol