| Company Name: |
DKMbiochem.Co. Ltd
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| Tel: |
15901859516 |
| Email: |
sales@DKMbiochem.com |
| Products Intro: |
Product Name:tert-butyl (1R,4S)-4-(hydroxyMethyl)cyclopent-2-enylcarbaMate
CAS:168960-18-7
Purity:95% Package:5g,10g,50g,100G
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| Company Name: |
Aikon International Limited
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| Tel: |
025-58859352 18068836627 |
| Email: |
sales01@aikonchem.com |
| Products Intro: |
Product Name:tert-Butyl ((1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)carbamate
CAS:168960-18-7
Purity:95+% Package:1g;5g;10g
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| | CARBAMIC ACID, [4(S)-(HYDROXYMETHYL)-2-CYCLOPENTEN-1-YL]-1,1-DIMETHYLETHYL ESTER, (1R-CIS)- Basic information |
| Product Name: | CARBAMIC ACID, [4(S)-(HYDROXYMETHYL)-2-CYCLOPENTEN-1-YL]-1,1-DIMETHYLETHYL ESTER, (1R-CIS)- | | Synonyms: | TERT-BUTYL CIS-[4(S)-(HYDROXYMETHYL)CYCLOPENT-2-EN-1(R)-YL]CARBAMATE;(1R,4S)-N-(tert-Butyloxycarbonyl)-1-amino-4-(hydroxymethyl)-2-cyclopentene;1-((1R,4S)-4-(Hydroxymethyl)cyclopent-2-en-1-yl)-2-methylpropan-2-yl carbamate;CARBAMIC ACID, [4(S)-(HYDROXYMETHYL)-2-CYCLOPENTEN-1-YL]-1,1-DIMETHYLETHYL ESTER, (1R-CIS)-;Carbamic acid, [(1R,4S)-4-(hydroxymethyl)-2-cyclopenten-1-yl]-, 1,1-;TERT-BUTYL (1R,4S)-4-(HYDROXYMETHYL)CYCLOPENT-2-ENYLCARBAMATE;tert-Butyl ((1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)carbamate;N-[(1R,4S)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]-carbamic Acid 1,1-Dimethylethyl Ester | | CAS: | 168960-18-7 | | MF: | C11H19NO3 | | MW: | 213.27 | | EINECS: | | | Product Categories: | N-BOC | | Mol File: | 168960-18-7.mol | ![CARBAMIC ACID, [4(S)-(HYDROXYMETHYL)-2-CYCLOPENTEN-1-YL]-1,1-DIMETHYLETHYL ESTER, (1R-CIS)- Structure](CAS/GIF/168960-18-7.gif) |
| | CARBAMIC ACID, [4(S)-(HYDROXYMETHYL)-2-CYCLOPENTEN-1-YL]-1,1-DIMETHYLETHYL ESTER, (1R-CIS)- Chemical Properties |
| Boiling point | 338.8±31.0 °C(Predicted) | | density | 1.09±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO; Methanol | | pka | 12.06±0.40(Predicted) | | form | Oil | | color | Yellow |
| | CARBAMIC ACID, [4(S)-(HYDROXYMETHYL)-2-CYCLOPENTEN-1-YL]-1,1-DIMETHYLETHYL ESTER, (1R-CIS)- Usage And Synthesis |
| Uses | N-?[(1R,?4S)?-?4-?(Hydroxymethyl)?-?2-?cyclopenten-?1-?yl]?-carbamic Acid 1,?1-?Dimethylethyl Ester is an intermediate in synthesizing ent-Abacavir (Abacavir EP Impurity A) (A105015), an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
| | CARBAMIC ACID, [4(S)-(HYDROXYMETHYL)-2-CYCLOPENTEN-1-YL]-1,1-DIMETHYLETHYL ESTER, (1R-CIS)- Preparation Products And Raw materials |
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