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3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one

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3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one Basic information
Product Name:3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one
Synonyms:1,2,4-Triazolo[4,3-a]pyrazin-8(5H)-one, 6,7-dihydro-3-(trifluoromethyl)-;Sitagliptin Impurity 114;3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3- a]pyrazin-8-one;3-(trifluoromethyl)-6,7-dihydro-[l,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one? (Sitagliptin Impurity）;3-(Trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one;3-(Trifluoromethyl)-6,7-dihydro-[1,2,4]tri
CAS:877402-45-4
MF:C6H5F3N4O
MW:206.13
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Mol File:877402-45-4.mol
3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one Structure
3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one Chemical Properties
density 1.90±0.1 g/cm3(Predicted)
solubility DMSO (Slightly), Methanol (Slightly)
pka12.69±0.20(Predicted)
form Solid
color Off-White to Light Grey
Safety Information
MSDS Information
3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one Usage And Synthesis
Uses3-(Trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one is an intermediate in the synthesis of Sitagliptin Triazecine Analog (S491015). Sitagliptin Triazecine Analog is related to the family of Sitagliptin compounds which has recently been approved for the therapy of type II diabetes.
3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one Preparation Products And Raw materials
Tag:3-(trifluoromethyl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one(877402-45-4) Related Product Information
Sitagliptin Impurity 77 Sitagliptin impurity 5 Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate Sitagliptin Impurity 34 (R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)- Sitagliptin Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate (R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione Sitagliptin Impurity 14 Sitagliptin Defuoro IMpurity 5 Sitagliptin DeaMino IMpurity 1 (S)-Sitagliptin Phosphate Sitagliptin Impurity 28 2,4,5-Trifluorobenzyl chloride 2-Chloromethyl-5-trifluoromethyl-[1,3,4]oxadiazole 2,2,2-Trifluoro-N'-(trifluoroacetyl)acetohydrazide