N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide

N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Suppliers list

Company Name:	Nanjing Dulai Biotechnology Co., Ltd.
Tel:	025-84699383-8003;025-846993838003-8003 18013301590
Email:	njduly@126.com

Company Name:	Shanghai EFE Biological Technology Co., Ltd.
Tel:	021-65675885 18964387627
Email:	info@efebio.com

Company Name:	Shanghai YuanYe Biotechnology Co., Ltd.
Tel:	15026964105
Email:	2881489226@qq.com

N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide manufacturers

N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Basic information

Product Name:	N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide
Synonyms:	VEGF RECEPTOR TYROSINE KINASE INHIBITOR II;Valatinib;Benzamide, N-(4-chlorophenyl)-2-[(4-pyridinylmethyl)amino]-;VEGFR-IN-1;VEGFR IN 1,VEGFRIN1;Gefitinib-d;VEGFR Tyrosine Kinase Inhibitor II;VEGFR Tyrosine Kinase
CAS:	269390-69-4
MF:	C19H16ClN3O
MW:	337.8
EINECS:
Product Categories:	Angiogenesis and Metastasis
Mol File:	269390-69-4.mol

N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Chemical Properties

Boiling point	463.6±40.0 °C(Predicted)
density	1.331±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 25 mg/ml
form	A crystalline solid
pka	12.62±0.70(Predicted)
color	White to off-white
InChI	1S/C19H16ClN3O/c20-15-5-7-16(8-6-15)23-19(24)17-3-1-2-4-18(17)22-13-14-9-11-21-12-10-14/h1-12,22H,13H2,(H,23,24)
InChIKey	GGPZCOONYBPZEW-UHFFFAOYSA-N
SMILES	Clc1ccc(cc1)NC(=O)c2c(cccc2)NCc3ccncc3

Safety Information

WGK Germany	WGK 1
Storage Class	11 - Combustible Solids

MSDS Information

N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Usage And Synthesis

Uses	VEGFR Tyrosine Kinase Inhibitor II is an agent that potently inhibits kinase activities of KDR, Flt-1 and c-Kit.
Biological Activity	Cell permeable: yes', 'Primary Target Kinase activities of KDR, Flt-1 and c-Kit', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 20 nM, 180 nM and 240 nM against kinase activities of KDR, Flt-1 and c-Kit, respectively
IC 50	KDR: 0.02 μM (IC₅₀); Flt-1: 0.18 μM (IC₅₀); EGFR: 0.24 μM (IC₅₀)

N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide Preparation Products And Raw materials

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