1951424-89-7 manufacturers
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| | 1951424-89-7 Basic information |
| Product Name: | 1951424-89-7 | | Synonyms: | CAS_1951424-89-7;Desthiobiotin-PEG4-propargyl;4-Imidazolidinehexanamide, 5-methyl-2-oxo-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl-, (4R,5S)-;Desthiobiotin Alkyne (CCT-1109);6-((4R,5S)-5-Methyl-2-oxoimidazolidin-4-yl)-N-(3,6,9,12-tetraoxapentadec-14-yn-1-yl)hexanamide | | CAS: | 1951424-89-7 | | MF: | C21H37N3O6 | | MW: | 427.54 | | EINECS: | | | Product Categories: | | | Mol File: | 1951424-89-7.mol |  |
| | 1951424-89-7 Chemical Properties |
| Boiling point | 648.979±50.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.075±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Storage temp. 2-8°C | | pka | 14.932±0.60(predicted) | | form | Viscous Liquid | | color | Light yellow to yellow |
| | 1951424-89-7 Usage And Synthesis |
| Uses | Desthiobiotin-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Desthiobiotin-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | 1951424-89-7 Preparation Products And Raw materials |
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