NH-bis(PEG1-azide) manufacturers
- NH-bis(PEG1-azide)
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2025-06-07
- CAS:2100306-81-6
- Min. Order: 250mg
- Purity: >95.00%
- Supply Ability: 250mg
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| | NH-bis(PEG1-azide) Basic information |
| | NH-bis(PEG1-azide) Chemical Properties |
| storage temp. | 2-8°C, sealed storage, away from moisture and light | | solubility | Soluble in Water, DMSO, DCM, DMF | | form | Liquid | | color | Colorless to light yellow | | InChI | InChI=1S/C8H17N7O2/c9-14-12-3-7-16-5-1-11-2-6-17-8-4-13-15-10/h11H,1-8H2 | | InChIKey | FXMWPZQWEUFICE-UHFFFAOYSA-N | | SMILES | N(CCOCCN=[N+]=[N-])CCOCCN=[N+]=[N-] |
| | NH-bis(PEG1-azide) Usage And Synthesis |
| Description | NH-bis(PEG1-azide) is a PEG linker containing an amino group with two azide groups. The amino group is reactive with carboxylic acids, activated NHS esters. The azide groups enable PEGylation via Click Chemistry. | | Uses | NH-bis(C2-PEG1-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH-bis(C2-PEG1-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | NH-bis(PEG1-azide) Preparation Products And Raw materials |
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