| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
marketing1@energy-chemical.com |
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| | DKYWVDODHFEZIM-KQORAOOSSA-N Basic information |
| | DKYWVDODHFEZIM-KQORAOOSSA-N Chemical Properties |
| density | 1.198±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White |
| | DKYWVDODHFEZIM-KQORAOOSSA-N Usage And Synthesis |
| Uses | Ketoprofen-13C,d3 is the 13C- and deuterium labeled Ketoprofen. Ketoprofen (RP-19583) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1]. | | Definition | ChEBI: Ketoprofen is an oxo monocarboxylic acid that consists of propionic acid substituted by a 3-benzoylphenyl group at position 2. It has a role as a non-steroidal anti-inflammatory drug, an antipyretic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an environmental contaminant, a xenobiotic and a drug allergen. It is a member of benzophenones and an oxo monocarboxylic acid. It is functionally related to a propionic acid. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223. DOI:10.1080/02688697.2018.1500521
[2] Palomer A, et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12(4):533-7. DOI:10.1016/s0960-894x(01)00800-9 |
| | DKYWVDODHFEZIM-KQORAOOSSA-N Preparation Products And Raw materials |
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