ALISKIREN HEMIFUMARATE manufacturers
|
| | ALISKIREN HEMIFUMARATE Basic information |
| Product Name: | ALISKIREN HEMIFUMARATE | | Synonyms: | CGP 60536 fumarate|||SPP 100 fumarate|||CGP 60536 fumarate;CGP60536B fumarate;SPP 100 fumarate|||CGP60536B fumarate;(2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-(propa n-2-yl)nonanamide, but-2-enedioic acid;(2S,4S,5S,7S)-N-(2-Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]octanamide fumarate | | CAS: | 1196835-68-3 | | MF: | C30H53N3O6.C4H4O4 | | MW: | 667.83 | | EINECS: | | | Product Categories: | | | Mol File: | 1196835-68-3.mol |  |
| | ALISKIREN HEMIFUMARATE Chemical Properties |
| | ALISKIREN HEMIFUMARATE Usage And Synthesis |
| Uses | Aliskiren is a highly potent and selective inhibitor of the human renin. | | in vivo | Aliskiren fumarate (< 10 mg/kg, Orally, daily) inhibits plasma renin activity and lowers blood pressure in sodium-depleted marmosets[2].
Aliskiren fumarate (10 mg/kg, Intragastrically, once) significantly alleviates multiple cachexiaassociated symptoms in BALB/c mice bearing C26 mouse colon carcinoma cells, including BW loss, tumor burden, muscle wasting, muscular dysfunction, and shortened survival[3]. |
| | ALISKIREN HEMIFUMARATE Preparation Products And Raw materials |
|