| Company Name: |
Shanghai Balmxy Pharmaceutical Co., Ltd
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| Tel: |
021-24206007 13764915196 |
| Email: |
sales@balmxy.com |
| Products Intro: |
Product Name:N-(4,6-Dichloropyrimidin-5-yl)formamide
CAS:123240-66-4
Purity:98%+ Package:5g;25g;100g;500g;1kg;5kg;25kg;100kg
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| Company Name: |
Cool Pharm, Ltd
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| Tel: |
021-60455363 18019463053 |
| Email: |
sales@coolpharm.com |
| Products Intro: |
Product Name:N-(4,6-Dichloropyrimidin-5-yl)formamide
CAS:123240-66-4
Purity:95.0% Package:10g;25g;100g;500g;1kg;5kg;10kg
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| Company Name: |
3A SpeedChemical Inc
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| Tel: |
21-65679720 |
| Email: |
service@speedchemical.com |
| Products Intro: |
Product Name:4,6-Dichloro-5-formamidopyrimidine
CAS:123240-66-4
Purity:97+% Package:USD648/5grams
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| Company Name: |
Aikon International Limited
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| Tel: |
025-58851090 15955137747 |
| Email: |
sales01@aikonchem.com |
| Products Intro: |
Product Name:N-(4,6-DICHLORO-PYRIMIDIN-5-YL)-FORMAMIDE
CAS:123240-66-4
Purity:95+% Package:1g;5g;10g
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| | N-(4,6-DICHLORO-PYRIMIDIN-5-YL)-FORMAMIDE Basic information |
| Product Name: | N-(4,6-DICHLORO-PYRIMIDIN-5-YL)-FORMAMIDE | | Synonyms: | AKOS 91530;N-(4,6-DICHLORO-PYRIMIDIN-5-YL)-FORMAMIDE;4,6-Dichloro-5-formamidopyrimidine;N-(4,6-Dichloropyrimidin-5-yl);Formamide, N-(4,6-dichloro-5-pyrimidinyl)-;N-(4,6-Dichloro-5-pyrimidinyl)formamide | | CAS: | 123240-66-4 | | MF: | C5H3Cl2N3O | | MW: | 192 | | EINECS: | | | Product Categories: | | | Mol File: | 123240-66-4.mol |  |
| | N-(4,6-DICHLORO-PYRIMIDIN-5-YL)-FORMAMIDE Chemical Properties |
| Boiling point | 420.1±45.0 °C(Predicted) | | density | 1.647±0.06 g/cm3(Predicted) | | pka | 11.28±0.70(Predicted) |
| | N-(4,6-DICHLORO-PYRIMIDIN-5-YL)-FORMAMIDE Usage And Synthesis |
| Synthesis | Acetic anhydride (50 mL) was slowly added dropwise to a suspension of formic acid (125 mL) of 4,6-dichloro-5-aminopyrimidine (10.37 g, 164 mmol) at 0 °C. The reaction mixture was then stirred at room temperature for 2.5 hours. Upon completion of the reaction, the volatile components were removed by distillation under reduced pressure. The resulting residue was co-evaporated three times with toluene (50 mL) to completely remove the residual solvent, resulting in N-(4,6-dichloropyrimidin-5-yl)formamide as a white solid (12.1 g, quantitative yield). The product was used for subsequent reactions without further purification.1H NMR (d6-DMSO) δ 8.32 (s, 1H), 8.83 (s, 1H, CHO), 10.51 (br s, 1H, NH). | | References | [1] Journal of Medicinal Chemistry, 1990, vol. 33, # 1, p. 187 - 196
[2] Tetrahedron Letters, 2011, vol. 52, # 48, p. 6415 - 6419
[3] Patent: CN108285471, 2018, A. Location in patent: Paragraph 0056-0057 |
| | N-(4,6-DICHLORO-PYRIMIDIN-5-YL)-FORMAMIDE Preparation Products And Raw materials |
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