| Company Name: |
Wuxi AppTec |
| Tel: |
022-59987777 13552403979 |
| Email: |
jia_guoqiang@wuxiapptec.com |
1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl cyclopropanecarboxylate hydrochloride(WXC08998) manufacturers
- OT-551 HCl
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- $117.00
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2026-05-11
- CAS:627085-15-8
- Purity: 99.71%
- Supply Ability: 10g
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| | 1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl cyclopropanecarboxylate hydrochloride(WXC08998) Basic information |
| Product Name: | 1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl cyclopropanecarboxylate hydrochloride(WXC08998) | | Synonyms: | 1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl cyclopropanecarboxylate hydrochloride(WXC08998);1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl cyclopropanecarboxylate hydrochloride;OT-551 HCl;OT-551 HCl, 10 mM in DMSO;OT-551 | | CAS: | 627085-15-8 | | MF: | C13H24ClNO3 | | MW: | 277.78756 | | EINECS: | | | Product Categories: | | | Mol File: | 627085-15-8.mol |  |
| | 1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl cyclopropanecarboxylate hydrochloride(WXC08998) Chemical Properties |
| Melting point | 224-228 °C (decomp) |
| | 1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl cyclopropanecarboxylate hydrochloride(WXC08998) Usage And Synthesis |
| Uses | OT-551 is a NF-κB inhibitor with antioxidant and anti-inflammatory effects. OT-551 has the potential for retinal diseases research[1][2]. | | in vivo | OT-551 (25-100 mg/kg; ip; once) provides RPE cell protection against acute light damage in albino rats[1]. | Animal Model: | Sprague-Dawley (SD) albino rats (6-7 weeks of age) exposure to 2700 lux white fluorescent light[1] | | Dosage: | 25, 50, or 100 mg/kg | | Administration: | ip; once | | Result: | Retinal pigment epithelium (RPE) damage index was significantly lower in the animals.
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| | References | [1] Masaki Tanito, et al. Protection of retinal pigment epithelium by OT-551 and its metabolite TEMPOL-H against light-induced damage in rats. Exp Eye Res. 2010 Jul;91(1):111-4. DOI:10.1016/j.exer.2010.04.012
[2] S. A. Mousa, et al. Anti-Angiogenesis Efficacy of the Novel NF-B and Oxidative Stress Inhibitor, OT-551. ARVO Annual Meeting Abstract. |
| | 1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl cyclopropanecarboxylate hydrochloride(WXC08998) Preparation Products And Raw materials |
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