格鲁米特 基本信息
| 中文名称 | 格鲁米特 |
|---|---|
| 中文同义词 | 3-乙基-3-苯基-2,6-哌啶二酮;DEA限制;导眠能;格鲁米特;DL-3-乙基-3-苯基-2,6-哌啶二酮;DL-格鲁米特 |
| 英文名称 | DL-Glutethimide |
| 英文同义词 | 2,6-piperidinedione,3-ethyl-3-phenyl;2-ethyl-2-phenyl-glutarimid;2-Phenyl-2-ethylglutaric acid imide;2-phenyl-2-ethylglutaricacidimide;3-Ethyl-3-phenyl-2,6-diketopiperidine;3-Ethyl-3-phenyl-2,6-dioxopiperidine;3-Phenyl-3-ethyl-2,6-diketopiperidine;3-Phenyl-3-ethyl-2,6-dioxopiperidine |
| CAS号 | 77-21-4 |
| 分子式 | C13H15NO2 |
| 分子量 | 217.26 |
| EINECS号 | 201-012-0 |
| 相关类别 | API |
| Mol文件 | 77-21-4.mol |
| 结构式 |  |
格鲁米特 性质
| 熔点 | 84°C |
|---|---|
| 沸点 | 357.82°C (rough estimate) |
| 密度 | 1.0960 (rough estimate) |
| 折射率 | 1.5300 (estimate) |
| 闪点 | 9℃ |
| 储存条件 | -20°C |
| 溶解度 | 可溶于氯仿（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | pKa 11.8 (Uncertain) |
| 颜色 | 灰白色至浅米色 |
| 水溶解性 | 0.95g/L(27 ºC) |
| CAS 数据库 | 77-21-4(CAS DataBase Reference) |
| NIST化学物质信息 | Glutethimide(77-21-4) |
安全信息
| 危险品标志 | Xn,T,F |
|---|---|
| 危险类别码 | 22-39/23/24/25-23/24/25-11 |
| 安全说明 | 36-45-36/37-16-7 |
| 危险品运输编号 | 3249 |
| WGK Germany | 1 |
| RTECS号 | MA4725000 |
| 危险等级 | 6.1(b) |
| 包装类别 | III |
| 海关编码 | 29251200 |
| 毒害物质数据 | 77-21-4(Hazardous Substances Data) |
| 毒性 | Glutethimide, and a structurally similar compound methyprylon, has been used occasionally as a sedative-hypnotic, although glutethimide’s use for longer than 3 days is not recommended and it is rarely, if ever, prescribed today. Glutethimide causes a skin rash in nearly 10% of those using it, and although it was once thought to produce less respiratory depression than the barbiturates its overdose fatality record is not good. Much of the drug’s action can be attributed to 4-hydroxyglutethimide, which is more than twice as potent and has a long half-life. Like many other sedativehypnotics, abrupt withdrawal after chronic use or abuse resembles that of ethanol or the barbiturates and must be managed accordingly. |
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