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| | CHLOROACETYL ISOCYANATE Basic information |
| | CHLOROACETYL ISOCYANATE Chemical Properties |
| Melting point | 25°C | | Boiling point | 50-55 °C/20 mmHg (lit.) | | density | 1.403 g/mL at 25 °C (lit.) | | refractive index | 1.4630 | | Fp | 61 °C | | storage temp. | -20°C | | solubility | sol benzene, THF, etc. | | form | Liquid | | color | Clear yellow | | Sensitive | Moisture Sensitive | | Merck | 14,2117 | | BRN | 1904273 | | InChI | 1S/C3H2ClNO2/c4-1-3(7)5-2-6/h1H2 | | InChIKey | MOVMEFHWBOWMFU-UHFFFAOYSA-N | | SMILES | ClCC(=O)N=C=O |
| Hazard Codes | C,T | | Risk Statements | 34-20/21/22-14-25-42 | | Safety Statements | 8-45-36/37/39-26 | | RIDADR | 3080 | | WGK Germany | 3 | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29291000 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 3 Oral
Resp. Sens. 1
Skin Corr. 1B |
| | CHLOROACETYL ISOCYANATE Usage And Synthesis |
| Chemical Properties | CLEAR YELLOW LIQUID | | Uses | Chloroacetyl isocyanate has been used in the synthesis of:
- fumagillin analogs
- 2-chloro-N-(4-oxocyclopent-2-enyl)-acetamide
| | Application | Chloroacetyl isocyanate can be used to prepare primary amides from Grignard reagents, monosubstituted ureas from primary amines, and from β-lactams. | | storage | Toxic, lachrymator, corrosive, reacts with moisture; refrigerate and store under nitrogen; should be handled in a fume hood. |
| | CHLOROACETYL ISOCYANATE Preparation Products And Raw materials |
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