链球菌溶素O
| 中文名称 | 链球菌溶素O |
|---|---|
| 中文同义词 | 链球菌溶素O;链球菌溶血素O;链球菌;溶血素 O;ATCC 15300 链球菌;化合物 T19565;链球菌溶血素O 来源于化脓链球菌;来自化脓性链球菌的链球菌溶血素O |
| 英文名称 | STREPTOLYSIN O |
| 英文同义词 | STREPTOLYSIN O;STREPTOLYSIN O REAGENT;Hemolysins O, Streptococcus group A;STREPTOLYSIN O GAMMA-IRRADIATED;STREPTOLYSIN O FROM STREPTOCOCCUS*PYOGEN ES;Einecs 308-500-3;Native Streptococcus pyogenes Streptolysin O;Streptococcus sp. |
| CAS号 | 98072-47-0 |
| 分子式 | NULL |
| 分子量 | 0 |
| EINECS号 | 308-500-3 |
| 相关类别 | 菌种;酶制剂;Antibiotics N-SSignal Transduction Research Tools;EnzymesApplication Index;Lysing Enzymes and Protoplast PreparationEnzymes, Inhibitors, and Substrates;BacteriaSignal Transduction Research Tools;Cell Lysis Reagents;Cell Signaling and Neuroscience;Enzymatic Cell Lysis and Protoplast Preparation;EnzymesEnzymes, Inhibitors, and Substrates;Mammalian;Toxins and Venoms;Antibiotics;Antibiotics A to;Cell Dissociation and Cell Lysis |
| Mol文件 | Mol File |
| 结构式 |
链球菌溶素O 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | 水中的溶解度为1mg/mL |
| 形态 | 冻干粉 |
| 颜色 | 白色 |
| 水溶解性 | H2O: soluble 1mg/mL |
| Specific Activity | 25,000-50,000U/vial |
Streptolysin O is a labile toxin, and, with time, activity is irreversibly lost. The rate of activity loss is slowed by incubation with 0.1 M 2-mercaptoethanol or 0.01 M ethylenediaminetetraacetic acid (EDTA).
Streptolysin O, belongs to the group of thiol-activated toxins, is a secreted virulence factor of GAS that induces apoptosis in neutrophils and macrophages at later time points (~4 h). Streptolysin O induces eukaryotic cell lysis in a cholesterol-dependent manner, is highly upregulated in the GAS M1T1 clone during bloodstream dissemination. Streptolysin O is known to promote Group A Streptococcus (GAS) resistance to phagocytic clearance by neutrophils, a critical first element of host defense against invasive bacterial infection.
安全信息
| 危险品运输编号 | UN 2811PIH 6.1 / PGI |
|---|---|
| WGK Germany | 3 |
| 存储类别 | 6.1A - 可燃，急性毒性物质（类别1和类别2） 剧毒的危险物质 |
| 危险性类别 | 急性毒性 类别2 经皮 急性毒性 类别2 吸入 急性毒性 类别2 经口 危害水生环境-长期危害 类别2 严重眼损伤 类别1 经皮刺激 类别2 |
| 提供商 | 语言 |
|---|---|
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-135416A | 链球菌溶素O Streptolysin O (≥1000000 units/mg) | 98072-47-0 | 100 KU | 8075元 |
| 2026/06/05 | HY-135416 | 链球菌溶素O Streptolysin O | 98072-47-0 | 25KU | 5580元 |