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Ziprasidone mesilate

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Ziprasidone mesilate Basic information
Product Name:Ziprasidone mesilate
Synonyms:2H-INDOL-2-ONE, 5-[2-[4-(1,2-BENZISOTHIAZOL-3-YL)-1-PIPERAZINYL]ETHYL]-6-CHLORO-1,3-DIHYDRO-, MONOMETHANESULFONATE, TRIHYDRATE;5-[2-[4-(1,2-benzisothiazol-3yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2h-indol-2-one mesilate;ziprasidone mesilate;ZIPRASIDONE MESYLATE;Ziprasidone mesylate trihydrate;2H-Indol-2-one, 5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-,monomethanesulfonate, trihydrate;Ziprasidone mesilate trihydrate CRS;Ziprasidone (mesylate hydrate)
CAS:199191-69-0
MF:C22H31ClN4O7S2
MW:563.09
EINECS:
Product Categories:
Mol File:199191-69-0.mol
Ziprasidone mesilate Structure
Ziprasidone mesilate Chemical Properties
Major Applicationpharmaceutical (small molecule)
InChIKeyWLQZEFFFIUHSJB-UHFFFAOYSA-N
SMILESC1(N2CCN(CC2)CCC2=CC3CC(=O)NC=3C=C2Cl)C2C=CC=CC=2SN=1.S(C)(O)(=O)=O.O.O.O
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
Hazard ClassificationsSkin Sens. 1
STOT RE 2
MSDS Information
Ziprasidone mesilate Usage And Synthesis
UsesAntipsychotic (central D2and 5HT2receptor antagonist).
DefinitionChEBI: The methanesulfonate trihydrate salt of ziprasidone.
Brand nameGeodon (Pfizer).
in vivo

Ziprasidone mesylate trihydrate (oral gavage; 20 mg/kg; once daily; 7 weeks) results in weight loss, low level physical activity, high resting energy expenditure and greater capacity for thermogenesis when subjected to cold[3].

Animal Model:Eight-week-old female Sprague-Dawley rats weighing 200 to 250 g[3]
Dosage:20 mg/kg
Administration:Oral gavage; 20 mg/kg; once daily; 7 weeks
Result:Gained significantly less weight (P = 0.031), had a lower level of physical activity (P = 0.016), showed a higher resting energy expenditure (P < 0.001), and displayed a greater capacity for thermogenesis when subjected to cold (P < 0.001).
IC 50Rat 5-HT2 Receptor: 0.42 nM (Ki); Rat 5-HT1A Receptor: 3.4 nM (Ki); Rat D2 Receptor: 4.8 nM (Ki)
Ziprasidone mesilate Preparation Products And Raw materials
Tag:Ziprasidone mesilate(199191-69-0) Related Product Information
N-Aminoethylpiperazine Pefloxacin mesylate ISOXADIFEN-ETHYL Indole-3-acetic acid Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Ethyl acrylate Ethyl acetate Ethylparaben Ethyl cyanoacetate Indometacin Ethyl pyruvate Ethyl formate Indole-3-butyric acid Ziprasidone Hydrochloride Ethanol etisazole 3-Piperazinobenzisothiazole hydrochloride Ziprasidone hydrochloride monohydrate