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| Products Intro: |
Product Name:GSK2807 Trifluoroacetate
CAS:2245255-66-5
Purity:>=95% Remarks:Reach out to us for more information about custom solutions.
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GSK2807 Trifluoroacetate manufacturers
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| | GSK2807 Trifluoroacetate Basic information |
| Product Name: | GSK2807 Trifluoroacetate | | Synonyms: | GSK2807 Trifluoroacetate;CS-2876;(S)-2-Amino-4-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(3-(dimethylamino)propyl)amino)butanoic acid 2,2,2-trifluoroacetic acid salt;GSK2807 TFA;GSK2807,Inhibitor,GSK2807 Trifluoroacetate,inhibit,GSK-2807 Trifluoroacetate,Histone Methyltransferase,GSK 2807,GSK-2807 | | CAS: | 2245255-66-5 | | MF: | C21H33F3N8O7 | | MW: | 566.54 | | EINECS: | 604-604-1 | | Product Categories: | | | Mol File: | 2245255-66-5.mol |  |
| | GSK2807 Trifluoroacetate Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | DMSO:250.0(Max Conc. mg/mL);441.28(Max Conc. mM)
Water:50.0(Max Conc. mg/mL);88.26(Max Conc. mM) | | form | Solid | | color | White to yellow |
| | GSK2807 Trifluoroacetate Usage And Synthesis |
| Uses | GSK2807 Trifluoroacetate is a potent, selective and SAM-competitive inhibitor of SMYD3, with a Ki of 14 nM and an IC50 of 130 nM[1][2]. | | IC 50 | SMYD3: 14 nM (Ki); SMYD3: 130 nM (IC50) | | References | [1] Van Aller GS, et al. Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets. Structure. 2016 May 3;24(5):774-781. DOI:10.1016/j.str.2016.03.010
[2] Kaniskan Hü, et al. Inhibitors of Protein Methyltransferases and Demethylases. Chem Rev. 2018 Feb 14;118(3):989-1068. DOI:10.1021/acs.chemrev.6b00801 |
| | GSK2807 Trifluoroacetate Preparation Products And Raw materials |
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