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Product Name:Carboxypyridostatin trifluoroacetate salt
CAS:2444713-88-4
Purity:>=95% (HPLC) Package:5MG Remarks:SML1176-5MG
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Shanghai YuanYe Biotechnology Co., Ltd.
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Product Name:Carboxy pyridostatin trifluoroacetate salt
CAS:2444713-88-4
Package:1ml Remarks:T97469
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Product Name:Carboxy pyridostatin trifluoroacetate salt
CAS:2444713-88-4
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Beijing Jin Ming Biotechnology Co., Ltd.
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| Products Intro: |
Product Name:Carboxy pyridostatin trifluoroacetate salt
CAS:2444713-88-4
Purity:98% Package:1mg;5mg;10mg;25mg
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| | CARBOXYPYRIDOSTATIN TRIFLUOROACETATE SALT Basic information |
| | CARBOXYPYRIDOSTATIN TRIFLUOROACETATE SALT Chemical Properties |
| storage temp. | -20°C | | solubility | Soluble in DMSO | | form | powder | | color | white to light brown |
| | CARBOXYPYRIDOSTATIN TRIFLUOROACETATE SALT Usage And Synthesis |
| Uses | Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand. Carboxy pyridostatin trifluoroacetate salt has a highly molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Carboxy pyridostatin trifluoroacetate salt reduces cell proliferation and hinders stress granule (SG) formation[1][2][3]. | | in vivo | Carboxy pyridostatin trifluoroacetate salt (10 mg/kg; i.p.; every 12 h; 3 injections) significantly reduces the number of PCNA-expressing cells in the adult SVZ and increases the number of OLIG2-expressing cells in the corpus callosum in mice[1].
| Animal Model: | C57BL/6 mice (both sexes, 1-2 months old)[1] | | Dosage: | 10 mg/kg (dissolved in phosphate-buffered saline) | | Administration: | Intraperitoneal injection, every 12 h, 3 injections | | Result: | Reduced the number of PCNA-expressing cells in the adult SVZ of mice, indicating a decrease in cell proliferation.
Increased the number of OLIG2-expressing cells in the corpus callosum.
Showed no increase in OLIG2-expression in the SVZ.
Affected the differentiation of neural stem and progenitor cells in different brain regions.
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| | References | [1] Goldberg DC, et al. Manipulating Adult Neural Stem and Progenitor Cells with G-Quadruplex Ligands. ACS Chem Neurosci. 2020;11(10):1504-1518. DOI:10.1021/acschemneuro.0c00194
[2] Rocca R, et al. Molecular recognition of a carboxy pyridostatin toward G-quadruplex structures: Why does it prefer RNA Chem Biol Drug Des. 2017 Nov;90(5):919-925. DOI:10.1111/cbdd.13015
[3] Turner M, et al. rG4detector, a novel RNA G-quadruplex predictor, uncovers their impact on stress granule formation. Nucleic Acids Res. 2022 Nov 11;50(20):11426-11441. DOI:10.1093/nar/gkac950 |
| | CARBOXYPYRIDOSTATIN TRIFLUOROACETATE SALT Preparation Products And Raw materials |
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