GAP19 TRIFLUOROACETATE SALT

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GAP19 TRIFLUOROACETATE SALT Basic information
Product Name:GAP19 TRIFLUOROACETATE SALT
Synonyms:GAP19 TRIFLUOROACETATE SALT
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MW:0
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Mol File:Mol File
GAP19 TRIFLUOROACETATE SALT Structure
GAP19 TRIFLUOROACETATE SALT Chemical Properties
storage temp. -20°C
solubility Water: 2 mg/ml
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MSDS Information
GAP19 TRIFLUOROACETATE SALT Usage And Synthesis
DescriptionGap 19 is a nonapeptide derivative of connexin43 (Cx43) and an inhibitor of Cx43 hemichannels.1,2 It suppresses the membrane charge transfer (Qm) in HeLa cells expressing Cx43 (IC50 = ~6.5 µM), as well as Cx43 hemichannel currents in isolated guinea pig cardiomyocytes when used at a concentration of 100 µM.1 Gap 19 inhibits glutamate-induced ATP release, a marker of Cx43 hemichannel activity, in primary mouse astrocytes.2 In vivo, Gap 19 (300 µg/kg, i.c.v.) decreases cortical neuronal loss, infarct volume, and the number of errors in a foot fault test in a mouse model of cerebral ischemia and reperfusion injury induced by middle cerebral artery occlusion (MCAO).3 It also reduces infarct size in a mouse model of myocardial ischemia and reperfusion injury induced by ligation of the left anterior descending (LAD) artery when administered at a dose of 25 mg/kg.1WARNING This product is not for human or veterinary use.
References[1] NAN WANG. Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.[J]. Basic Research in Cardiology, 2013, 108 1: 309. DOI: 10.1007/s00395-012-0309-x
[2] VERÓNICA ABUDARA. The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes.[J]. Frontiers in Cellular Neuroscience, 2014: 306. DOI: 10.3389/fncel.2014.00306
[3] BEILEI CHEN . Inhibition of Connexin43 hemichannels with Gap19 protects cerebral ischemia/reperfusion injury via the JAK2/STAT3 pathway in mice[J]. Brain Research Bulletin, 2019, 146: Pages 124-135. DOI: 10.1016/j.brainresbull.2018.12.009
GAP19 TRIFLUOROACETATE SALT Preparation Products And Raw materials
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Tat-M2NX (trifluoroacetate salt) Gap 27 (trifluoroacetate salt) L-Cysteinamide, L-cysteinyl-L-lysylglycyl-L-lysylglycyl-L-alanyl-L-lysyl-L-cysteinyl-L-seryl-L-arginyl-L-leucyl-L-methionyl-L-tyrosyl-L-α-aspartyl-L-cysteinyl-L-cysteinyl-L-threonylglycyl-L-seryl-L-cysteinyl-L-arginyl-L-serylglycyl-L-lysyl-, cyclic (1→16),(8→20),(15→25)-tris(disulfide), 2,2,2-trifluoroacetate (1:?) Tat-Gap 19 (trifluoroacetate salt) GAP 26